免疫抑制剂环磷酰胺治疗急性间质性肾炎的临床效果  

Clinical effect of immunosuppressant Cyclophosphamide in the treatment of acute interstitial nephritis

作　　者：金碧辉[1] 王彩虹[1] 

机构地区：[1]内蒙古自治区赤峰市医院肾脏内科,内蒙赤峰024000

出　　处：《中国当代医药》2017年第31期83-85,共3页China Modern Medicine

摘　　要：目的探讨免疫抑制剂环磷酰胺治疗急性间质性肾炎的临床效果。方法选取我院2015年6月~2017年4月收治的30例急性间质性肾炎患者作为研究对象,按治疗方式的不同分成对照组和治疗组,每组15例。对照组患者采用激素进行治疗,治疗组患者采用激素联合环磷酰胺免疫抑制剂治疗,比较两组患者的相关生化指标(主要包括血尿酸、血尿素氮、血肌酐、内生肌酐清除率)的改善情况、住院天数、不良反应发生率、治疗总有效率。结果两组患者治疗前的血尿酸、血尿素氮、血肌酐、血肌酐清除率水平比较,差异无统计学意义(P>0.05)。治疗组患者治疗后的血尿酸、血尿素氮、血肌酐等生化指标水平明显低于对照组,血肌酐清除率明显大于对照组,差异有统计学意义(P<0.05)。治疗组患者的住院天数明显短于对照组,差异有统计学意义(P<0.05)。治疗组患者的不良反应发生率为6.7%,明显小于对照组的13.3%,差异有统计学意义(P<0.05)。结论采用环磷酰胺免疫抑制剂对急性间质性肾炎患者进行治疗,能有效改善患者生化指标,从而快速促进患者肾功能恢复,且药效安全可靠。Objective To investigate the clinical effect of immunosuppressant Cyclophosphamide in the treatment of acute interstitial nephritis.Methods 30 patients with acute interstitial nephritis who were admitted to our hospital from June 2015 to April 2017 were enrolled as the study subjects.According to the different treatment methods,the patients were divided into the control group and the treatment group,with 15 cases in each group.Patients in the control group were given hormones,and patients in the treatment group were given hormones combined with cyclophosphamide im- munosuppressant.Improvement of relevant biochemical indicators （including serum uric acid,blood urea nitrogen,serum ereatinine,endogenous ereatinine clearance rate）,the length of hospital stay,the incidence rate of adverse reactions,the total effective rate of treatment were compared between the two groups.Results There were no significant differences in the relevant biochemical indicators of serum uric acid,blood urea nitrogen,serum creatinine,endogenous creatinine clear- ance rate between the two groups before treatment （P〉0.05）.The level of serum uric acid,blood urea nitrogen,serum cre- atinine in the treatment group after treatment were significantly lower than those in the control group,the level of serum creatinine clearance rate in the treatment group after treatment was significantly higher than the control group,with significant difference （P〈0.05）.The length of hospital stay in the treatment group was significantly shorter than that in the control group,with significant difference （P〈0.05）.The incidence rate of adverse reactions in the treatment group was 6.7%,which was significantly less than 13.3% in the control group,with significant difference （P〈0.05）.Conclusion The application of Cyelophosphamide immunosuppressant in the treatment of patients with acute interstitial nephritis can ef- fectively improve the biochemical indicators of patients,so as to rapidly promote the recovery of renal function in patients,an

关 键 词：免疫抑制剂环磷酰胺 激素 急性间质性肾炎 临床效果 

分 类 号：R692.3[医药卫生—泌尿科学]