大黄红藤消炎方对急性重症胰腺炎患者肠道黏膜屏障功能的保护作用  

The protective effect of Dahuang Hongteng anti-inflammatory decoction on the intestinal barrier of the patients with acute pancreatitis

作　　者：闫玉红 陈玉梅 苗纯 王丽华 田志颖 王品艳 张丽贤 

机构地区：[1]河北医科大学附属哈励逊国际和平医院消化内科,河北衡水053000 [2]河北医科大学附属哈励逊国际和平医院微机管理中心,河北衡水053000

出　　处：《中国医院药学杂志》2017年第19期1961-1964,共4页Chinese Journal of Hospital Pharmacy

基　　金：河北省衡水市科学技术研究与发展计划资助项目(编号:15012)

摘　　要：目的:探讨对急性重症胰腺炎患者使用大黄红藤消炎方治疗后对其肠黏膜屏障功能的保护作用。方法:选取河北医科大学附属哈励逊国际和平医院消化内科收治的急性重型胰腺炎患者80名作为研究对象,对照组与观察组按随机法进行分配,对照组40名采用常规一般治疗,观察组40名除常规治疗外加用大黄红藤消炎方辅助治疗,比对两组间DAO、D-乳酸与内毒素水平,记录初次排便时间、腹胀改善时间、腹痛改善时间,比较总有效率。结果:治疗前对照组DAO、D-乳酸与内毒素水平和观察组相对比,差异无统计学意义(P>0.05)。治疗后观察组DAO、D-乳酸与内毒素水平相比对照组明显下降,差异有显著性统计学意义(P<0.05)。观察组初次排便时间、腹胀改善时间、腹痛改善时间均少于对照组,差异有显著性统计学意义(P<0.05)。治疗组总有效率显著高于对照组(P<0.05)。结论:对急性重症胰腺炎患者使用大黄红藤消炎方辅助治疗后能够促进肠道蠕动,改善肠麻痹,更加有效降低DAO、D-乳酸及内毒素的值,从而起到保护肠黏膜屏障,改善重症胰腺炎患者预后的作用。OBJECTIVE To investigate the protective effect of Dahuang Hongteng anti-inflammatory decoction on the intesti- nal barrier of the patients with severe acute pancreatitis. METHODS Totally 80 patients with severe acute pancreatitis were re- viewed in Department of Gastroenterology. at Harrison International Peace Hospital Affiliated to Hebei Medical University, ran- domly divided into control group and observation group. Patients in the control group received conventional treatment, patients in observation group received Dahuang Hongteng anti-inflammatory decoction on the basis of conventional treatment. The levels of DAO,D-lactate,endotoxin and the initial defecation time, soothing times of abdominal pain and abdominal distension of the two groups were recorded to evaluate the curative effects. The total effective rates of the two groups were Compared. RESULTS The levels of DAO, D-lactate and endotoxin before treatment were not significantly different between the two groups （P〈 0. 05）. The levels of DAO, D-lactate and endotoxin were reduced in observation group after treatment （P〈0. 05）. Compared with the control group, the initial defecation time and the soothing times of abdominal pain and abdominal distension were sig- nificantly shortened in the observation group （P〈0. 05）. The total effective rate in treatment group was significantly higher than in the control group （P〈0. 05）. CONCLUSION In patients with severe acute pancreatitis, conventional treatment combined with Dahuang Hongteng anti-inflammatory decoction can promote enterocinesia, improve enteroplegia, lower the levels of DAO,D-lactate and endotoxin,and thus protect the intestinal mucosa and improve the prognosis of the patients with severe acute pancreatitis.

关 键 词：大黄红藤消炎方 急性重症胰腺炎 肠黏膜屏障功能 

分 类 号：R975[医药卫生—药品]