无机纳米材料基因载体系统的研究进展  

Research progress in inorganic nano-materials-based gene delivery system

作　　者：王悦敏[1] 赵嘉兰 牛亚伟[1] 董晓婷[1] 秦凌浩[1] 

机构地区：[1]广东药科大学药剂系,广州510006

出　　处：《中国新药杂志》2017年第21期2551-2558,共8页Chinese Journal of New Drugs

基　　金：广东省自然科学基金资助项目(2014A030310362);广州市科技计划项目(201508010036;201605131249066)

摘　　要：安全有效的基因载体系统对基因治疗有着重要的潜在价值。相对于病毒型基因载体,非病毒基因载体具有低免疫原性、易于大规模生产的特点,因而受到越来越多的关注。纳米材料由于具有粒径小、制备简单、易于表面修饰以及良好的生物相容性等优势,使得该类载体介导的基因治疗具有较低的毒副作用以及较高的转染效率。本文将基于近年来纳米材料基因载体的最新研究,对金属纳米材料、介孔二氧化硅纳米材料、荧光碳点纳米材料以及无机钙盐纳米材料等基因载体进行介绍及分析。Development of safe and efficient gene carriers for nucleic acid drug delivery is significant and has great potential for the treatment of genetic diseases. With the concerns of immunogenicity and feasibility for large-scale production,non-viral gene vectors have attracted considerable attention compared with viral gene vectors.The nano-materials gene carriers have more advantages including uniform particle size,simple preparation,easy surface modification and good biocompatibility,which can improve cell transfection efficiency and reduce cytotoxicity.In this paper,based on the newest researches of nano-material carriers,a detailed review and brief analysis of non-viral gene vectors including metal nano-materials,mesoporous silica nano-materials,inorganic calcium nano-materials and fluorescent carbon dots nano-materials were made.

关 键 词：非病毒基因载体 纳米材料 安全性 转染效率 

分 类 号：R944[医药卫生—药剂学]