佛香饮方对寒凝血瘀型痛经模型大鼠痛反应及血液流变学的影响  

Foxiangyin on the Model Rats with Cold Coagulation and Blood Stasis Dysmenorrhea Pain Reaction and Blood Rheology

作　　者：缪希红[1] 冯晓静 杨新蕊 白云鹤 

机构地区：[1]河北省承德市中心医院,河北承德067000 [2]河北省承德市第三医院,河北承德067000

出　　处：《河北医学》2017年第11期1791-1795,共5页Hebei Medicine

基　　金：河北省中医药管理局资助项目;(编号:2016159)

摘　　要：目的:探讨佛香饮方水提取物对寒凝血瘀型痛经模型大鼠的镇痛作用及其对血液流变性的影响,为其临床应用提供实验依据。方法:采用冰水浴、皮下注射盐酸肾上腺素,加ip注射缩宫素法建立大鼠寒凝血瘀型痛经模型。以扭体反应次数为指标,探讨佛香饮对痛反应的影响。以凝血时间(CT)、凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)及血小板聚集率、红细胞压积(HCT)、血沉方程K值、血浆黏度、全血黏度为指标,探讨佛香饮对寒凝血瘀型痛经模型大鼠对凝血及血液流变学指标的影响。结果:佛香饮1.8g/kg,3.6g/kg和7.2g/kg剂量组大鼠的CT明显长于模型对照组(P<0.05或P<0.01),PT、TT及APTT均明显高于模型组(P<0.05或P<0.01)。佛香饮3.6g/kg和7.2g/kg剂量组的血小板聚集率明显低于模型组(P<0.05或P<0.01),HCT、血沉方程K值均明显低于模型对照组(P<0.05);佛香饮各剂量组血浆黏度、全血黏度均低于模型对照组(P<0.05或P<0.01)。结论:佛香饮对寒凝血瘀型痛经模型大鼠的镇痛和改善血液流变性作用是其治疗寒凝血瘀型痛经的主要作用基础。Objective: To investigate the effects of water extract from Foxiang Yin( FXY) on pain reaction and hemorheological parameters of rats with dysmenorrhe induced by cold coagulation and blood stasis to provide the experimental basis for clinical application of the prescription. Methods: The rats dysmenorrhea model induced by cold congealing and blood stasis were made by ice water bath and subcutaneous injection of adrenaline hydrochloride( Adr) combined with intraperitoneal injection of oxytocin. The inhibition rate of pain reaction was were calculated. The prothrombin time( PT),thrombin time( TT),activated partial thromboplastin time( APTT),the rate of platelet aggregation,hematocrit( HCT),K value of erythrocyte sedimentation equation,plasma viscosity and whole blood viscosity were detected. Results: The CT,PT,TT and APTT in1.8 g/kg,3. 6 g/kg and 7. 2 g/kg doses groups of FXY are significantly longer than that in the model control group( P <0.05 or P < 0. 01). The platelet aggregation rate in high and middle 3. 6 g/kg and 7. 2 g/kg dose of FXY group were significantly lower than that of model group( P < 0.05 or P < 0.01). The hematocrit( HCT)and ESR equation K values in all doses of FXY groups were significantly lower than that of model group( P <0.05). The plasma viscosity and whole blood viscosity in all dosage of FXY groups were lower than that of model group( P < 0. 05 or < P 0. 01). Conclusion: FXY has obvious analgesic effect on the cold coagulation and blood stasis dysmenorrhea rats and improve high agglutination condition of blood and hemorheology is one of its action mechanisms.

关 键 词：佛香饮 痛经 痛反应 寒凝血瘀 血液流变学 

分 类 号：R285.5[医药卫生—中药学] R-332[医药卫生—中医学]