低频脉冲电磁场促进骨愈合的Meta分析  

Low frequency-pulsed electromagnetic fields promote bone healing: a Meta-analysis

作　　者：赵新娟 张静[2] 尹博[2] 亢依婷 

机构地区：[1]乐山师范学院体育学院,四川省乐山市614000 [2]陕西师范大学体育学院,陕西省西安市710119

出　　处：《中国组织工程研究》2017年第32期5234-5239,共6页Chinese Journal of Tissue Engineering Research

基　　金：陕西师范大学研究生培养创新基金(2015CXS020)~~

摘　　要：背景:临床研究证实了低频脉冲电磁场除了用于骨折延迟愈合与骨不连外,对新鲜骨折、骨切除术及疲劳骨折的治疗也有显著疗效。目的:系统评价低频脉冲电磁场促进骨愈合的临床疗效和安全性。方法:通过检索中国学术期刊全文数据库(CNKI)、美国国立医学图书馆生物医学信息检索系统(Pub Med)等数据库中1985年1月至2016年5月有关低频脉冲电磁场促进骨折愈合的随机对照临床研究文献,对纳入文献进行资料提取、方法学质量评价,并采用Rev Man5.1软件进行统计分析。结果与结论:(1)有13篇文献符合纳入标准,共有1 244例患者,均为随机对照临床试验;(2)Meta分析结果显示:低频脉冲电磁场治疗组的总体有效率高于对照组的总体有效率;治疗组的骨折愈合时间显著低于对照组的骨折愈合时间;治疗组的骨密度显著高于对照组的骨密度;(3)结果说明,低频脉冲电磁场促进骨折愈合的总有效率较高,能显著缩短骨折愈合时间且安全性较高,但还需要大量Jadad法评分高的多中心、大样本量随机对照临床试验来进一步验证。METHODS： CNKI and PubMed databases were retrieved for the randomized controlled trials concerning LF-PEMFspromoting bone healing published from January 1985 to May 2016. Meta-analysis was conducted on RevMan 5.1software after data management and quality assessment.RESULTS AND CONCLUSION： Thirteen eligible literatures were enrolled, involving 1244 patients. Meta-analysisshowed that the overall effectiveness and bone mineral density in the LF-PEMFs group were significantly higher thanthose in the control group. The healing time in the LF-PEMFs group was significantly shorter than that in the controlgroup. These results suggest that LF-PEMFs show high efficacy and safety for bone healing, and also can markedlyshorten the healing time. However, more high-quality multi-center, large-scale randomized controlled trials are stillneeded to testify all above conclusions.

关 键 词：组织构建 骨组织工程 低频脉冲电磁场 骨折 疗效 META分析 

分 类 号：R318[医药卫生—生物医学工程]