卡托普利-维多利亚蓝B体系的共振瑞利散射光谱及应用  

The resonance rayleigh scattering spectra of captopril with victoria blue B system and their applications

作　　者：蒋天艳 冉金凤 解小华 江虹[1] 

机构地区：[1]长江师范学院化学化工学院,重庆408100

出　　处：《化学研究与应用》2017年第11期1710-1713,共4页Chemical Research and Application

基　　金：重庆市教委科技基金项目(KJ1401226)资助;长江师范学院科技基金项目(2015CXX079)资助

摘　　要：建立了快速测定卡托普利的共振瑞利散射法,探讨了共振瑞利散射光谱特征和共存物质的影响。在弱碱性溶液中,卡托普利与维多利亚蓝B反应生成蓝色二元离子缔合物,使体系的共振瑞利散射(RRS)信号显著增强,最大RRS峰位于356nm,体系的RRS增强程度△IRRS与0.004~0.22mg·L^(-1)范围内的卡托普利的质量浓度呈线性关系,检出限为0.0035 mg·L^(-1)。方法用于药物中卡托普利的测定,回收率为99.21~102.3%,相对标准偏差RSD(n=5)为1.8~2.4%。A new resonance Rayleigh scattering method for the rapid determination of captopril was established. The resonance Ray-leigh scattering spectral characteristics and the effects of coexisting substances were discussed. In a weak alkaline solution,the cap-topril reacts with victoria blue B to form a blue binary ionic association complexes, which led to a distinctly enhanced resonance Rayleigh scattering（ RRS） signal of system. The maximum resonance Rayleigh scattering peak was located at 356 nm. The resonance Rayleigh scattering enhance intensity A/RRSwas directly proportional to the mass concentration of captopril in the range of 0. 004 to 0. 22 mg ·L^-1 with the detection limit was 0. 0035 mg·L^-1. The method has been applied to the determination of captopril in com-mercially available captoril drugs with the values of recovery and RSD（ n = 5 ） found were in the ranges of 99. 21 ？102. 3 % and 1. 8 - 2. 4% respectively.

关 键 词：卡托普利 维多利亚蓝B 药物 共振瑞利散射 

分 类 号：O657.39[理学—分析化学]