香砂六君子汤合艾箱灸对脾虚型慢性萎缩性胃炎大鼠胃动素影响的实验研究  

Experimental Study on the Effect of Xiangsha Liujunzi Decoction Plus Moxa on Motilin for Rats with Spleen Deficiency Type Chronic Atrophic Gastritis

作　　者：李玉玲[1] 吴庆和 黄穗平 LI Yuling;WU Qinghe;Huang Suiping(Gastroenterology Department, Wuhan Municiopal Hospital of Integrative Medicine,Hebei Wuhan 430022, China;The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou Guandong 510120, China)

机构地区：[1]武汉市中西医结合医院消化科,湖北武汉430022 [2]广东省中医院广州中医药大学第二临床医学院,广东广州510120

出　　处：《四川中医》2017年第10期61-63,共3页Journal of Sichuan of Traditional Chinese Medicine

基　　金：广东省科技厅项目(编号:2013B022000090)

摘　　要：目的:通过观察香砂六君子汤合艾箱灸对慢性萎缩性胃炎大鼠胃动素含量的影响,探讨香砂六君子汤合艾箱灸治疗慢性萎缩性胃炎的作用机理。方法:65只大鼠随机分为空白组、模型组、中药组、中药+胃复春组、中药+艾箱灸组共5组,采用自由饮用MNNG溶液,隔日灌胃去氧胆酸钠溶液及配合单双日饥饱交替法诱发脾虚型慢性萎缩性胃炎大鼠模型。艾灸选取"足三里"及"中脘"穴,灌胃中药选用香砂六君子汤。造模成功时及治疗结束后Elisa法测定各组大鼠胃动素水平。结果:慢性萎缩性胃炎模型组大鼠血浆MTL水平显著升高;治疗组均能显著降低CAG大鼠的血浆MTL水平。结论:香砂六君子汤合艾箱灸通过降低血浆胃动素水平以产生正常的胃肠蠕动,促进胃的排空,缩短损伤因子在胃内的滞留,起到胃肠清道夫的作用,从而发挥预防及治疗慢性萎缩性胃炎的作用。Objective：To observe the effect of herbs and moxibustion on motilin in rats with chronic atrophic gastritis（CAG）in order to explore its mechanism.Methods：Sixty-five SD rats were evenly and randomly divided into controlled group,mode 1 group,herbs group,herbs and Weifuchun group,herbs and moxibustion group.CAG model was established by feeding the rats with MNNG solution,and oxygen bile acid sodium solution every other day,and hunger alternate methd continuously for8 weeks.Herbs cont-ained Dangshen（Radix Oedonopsis Pilosulae）,Baizhu（Rhizoma Atractylodis Macrocephalae）,Fuling（Poria cocos）,Muxiang（Radix Aucklandiae）,Sharen（fructus amomi）,Gancao（licorice root）,Faxia（Rhizoma Pinellinae Praeparata）,Chenpi（Pericarpurn Citri Retioulatae）,etc.Plasma motilin contents were determined with Elisa Radioi-mmunoassay.Results：In comparison with the controlled group,plasma motilin content increased significantly in the model group（P〈0.05）;while compared with the model group,plasma motilin contents in three treatment groups decreased significantly;In three treatment groups,plasma motilin was lowest in herbs and Weifuchun group,and then herbs and moxibustion groups and herbs groups.Conclusion：Herbs and moxibustion can apparently regulate the levels of plasma motility in CAG rats,produce normal gastrointestinal peristalsis and promote gastric emptying to shorten gastric retention of the damage factor,and thus have effect of gastrointestinal scavenger,which can play role in prevention and treatment of chronic atrophic gastritis.

关 键 词：慢性萎缩性胃炎 香砂六君子汤合艾箱灸 胃肠动力 胃动素 实验研究 

分 类 号：R285.5[医药卫生—中药学]