管灸对面神经损伤模型家兔TrkA表达的影响  

Effect of Guan-moxibustion on the Expression of TrkA for Rabbit Model of Facial Nerve Injury

作　　者：杨金蓉[1] 宋军[2] 田丰玮 黄永滕 黄靖云[1] 赵金发[1] 

机构地区：[1]成都中医药大学,四川成都610075 [2]四川省中医药科学院,四川成都610041 [3]重庆市中医研究院,重庆400013

出　　处：《四川中医》2017年第11期51-53,共3页Journal of Sichuan of Traditional Chinese Medicine

基　　金：国家自然基金课题(编号:81373740);四川省教育厅重点课题(编号:132A0276)

摘　　要：目的:探讨管灸治疗面神经损伤的机理。方法:采用机械压榨制作家兔面神经损伤模型,采免疫组化技术、原位杂交技术观察管灸对其面神核、面神经TrkA蛋白和mRNA表达的影响,并和热疗进行对比。结果:与模型组比较,管灸组各部位TrkA蛋白和mRNA表达均增加,有显著性差异(P<0.05或0.01)。热疗组各部位均无明显增加。结论:管灸可显著增加各部位TrkA的表达,从而促进面神经损伤的修复和再生。Objective： To reveal the molecular mechanisms of Guan-moxibustion in the treatment of facial neuritis. Meth-ods ： With the model of rabbits in Sunderland III injury in facial nerve, they were randomly divided into 4groups, sham operationgroup, model group, Guan-moxibustion group and hyperthermia group. Applying immunohistochemistry and in situ hybridiza-tion to compare the expression of tyrosine kinase A （TrkA） protein and mRNA the nucleus of facial nerve and facial nerve amongthe groups. Results： Comparing with the model groups and the hyperthermia groups, hyperthermia expression of TrkA proteinand mRNA in the nucleus of facial nerve, facial nerve and mimetic muscle of Guan-moxibustion group is obviously increased （P〈0. 05 ）. Conclusions ： Guan-moxibustion can obviously increase the expression of TrkA in the nucleus of facial nerve and facialnerve.

关 键 词：管灸 面神经损伤 TRKA 

分 类 号：R245.8[医药卫生—针灸推拿学]