酸枣仁、覆盆子对酒精戒断焦虑征的治疗作用  

Effect of raspberry and Semen Ziziphi Spinosae extract on anxiety of ethanol withdrawal

作　　者：邢宇双 梁启超[1] 郑科文[2] 宋小欣 雷涛[1] 吴宜艳[1] 杨志[3] 

机构地区：[1]牡丹江医学院药学院,黑龙江牡丹江157011 [2]牡丹江医学院红旗医院,黑龙江牡丹江157000 [3]牡丹江医学院第二附属医院,黑龙江牡丹江157010

出　　处：《实验室科学》2017年第5期28-31,35,共5页Laboratory Science

基　　金：黑龙江省自然科学基金委员会"针刺调节杏仁核治疗大鼠酒精戒断焦虑症的物质基础"(项目编号:H201495)

摘　　要：研究酸枣仁、覆盆子对酒精戒断焦虑症的治疗作用,并探讨其作用机制。研究方法选取健康SD大鼠随机分组,腹腔注射酒精28天,给药治疗3天,最后一次给药1h后,高架十字迷宫测其焦虑行为,HPLC测海马中去甲肾上腺素的含量。结果与模型组相比,大剂量覆盆子提取物、大剂量炒制酸枣仁醇提物在高架十字迷宫测试中能显著增加其次数、时间(P<0.05),在HPLC检测中可降低海马中去甲肾上腺素含量(P<0.05),且酸枣仁作用更为显著。由此得出结论,覆盆子提取物、炒制酸枣仁醇提物能减轻酒精戒断时大鼠所表现出的焦虑样行为,其抗焦虑症的作用机制可能与降低大鼠海马组织中去甲肾上腺素含量有关。Objective ： We investigated the effect of raspberry and Semen Ziziphi Spinosae on anxiety- like behavior and the levels of norepinephrine in Hippocampus during ethanol withdrawal in rats. Methods Healthy SD rats were randomly divided. In addition to the blank group, the remaining groups were intraperitoneally injected with 20% （w/v） alcohol for 28 days, and then the drug was given for 3 days. One hour after the last administration, the anxiety behavior was measured by the elevated cross maze, and the content of norepinephrine in the hippocampus was determined by HPLC. Results ： Rats undergoing ethanol withdrawal exhibited substantial anxiety-like behavior, which were greatly attenua- ted by doses of raspberry and stir-frying Semen Ziziphi Spinosae. The high performance liquid chroma- tography analysis revealed that ethanol withdrawal significantly increased norepinephrine levels in the hippocampus. Conclusions： These results suggest that raspberry and Semen Ziziphi Spinosaeeattenuate anxiety-like behavior induced by ethanol withdrawal through modulation of the hypothalamic norepi- nephrine system in the brain.

关 键 词：覆盆子 酸枣仁 酒精戒断 焦虑 

分 类 号：R96[医药卫生—药理学]