清脑舒郁汤对肝气郁结型偏头痛伴抑郁焦虑患者的临床疗效研究  

Clinical effect of Qingnao Shuyu decoction in treatment of migraine with stagnation of liver qi complicated by depression and anxiety: an analysis of 30 cases

作　　者：张希 李赵军 邓婷 郭慧 ZHANG Xi;LI Zhao - jun;DENG Ting;GUO Hui(Changsha Hospital of Traditional Chinese Medicine, Changsha 410002 ,Hunan, China)

机构地区：[1]湖南省长沙市中医院,湖南长沙410002

出　　处：《湖南中医杂志》2017年第10期9-12,共4页Hunan Journal of Traditional Chinese Medicine

基　　金：湖南省科技厅科技计划项目(编号:2013SK3235)

摘　　要：目的:探讨清脑舒郁汤对肝气郁结型偏头痛伴抑郁焦虑患者的临床疗效。方法:将60例肝气郁结型偏头痛伴抑郁焦虑患者随机分为2组各30例,治疗组予清脑舒郁汤治疗,对照组予西比灵治疗,疗程均为30d。观察比较2组治疗前后头痛程度(VAS评分)、头痛发作频率及持续时间、汉密尔顿焦虑量表(HAMA)及汉密尔顿抑郁量表(HAMD)评分,评定2组综合疗效。结果:治疗组、对照组临床总有效率分别为86.7%、63.3%,组间比较,差异有统计学意义(P<0.05);2组治疗后VAS评分、头痛发作频率及持续时间均较治疗前有显著改善(P<0.05),且治疗组改善优于对照组(P<0.05);治疗组治疗后HAMA和HAMD评分均较治疗前明显降低(P<0.05),且优于对照组治疗后(P<0.05),而对照组治疗前后差异不明显(P>0.05)。结论:清脑舒郁汤可有效降低肝气郁结型偏头痛伴抑郁焦虑患者的偏头痛发作频率,缩短头痛持续时间,减轻头痛程度,有效改善头痛患者伴随的抑郁焦虑情绪障碍。Objective：To investigate the Clinical effect of Qingnao Shuyu decoction in the treatment of migraine with stagnation of liver qi complicated by depression and anxiety. Methods：A total of 60 patients with migraine with stagnation of liver qi complicated by depression and anxiety were randomly divided into treatment group and control group, with 30 patients in each group. The patients in the treatment group were given Qingnao Shuyu decoction, and those in the control group were given Sibelium. The course of treatment was 30 days for both groups. The two groups were compared in terms of severity of headache [ Visual Analogue Scale （ VAS ） score ], frequency and duration of headache attacks, Hamilton Anxiety Scale （HAMA） score, and Hamilton Depression Scale （HAMD） score before and after treatment, and the overall treatment outcome was determined for both groups. Results：There was a significant difference in overall response rate between the treatment group and the control group（86. 7% vs 63.3% ,P 〈0. 05）. Both groups had significant improvements in VAS score and frequency and duration of headache attacks after treat- ment （ P 〈 0. 05 ）, and the treatment group had significantly greater improvements than the control group （P 〈 0. 05 ）. After treatment, the treatment group had significant reductions in HAMA and HAMD scores （ P 〈 0.05 ）, while the control group showed no significant changes in these scores （P 〈 0.05 ） ;the treatment group had better HAMA and HAMD scoresafter treatment than the control group （ P 〉 0.05 ）. Conclusion ： In patients withmigraine with stagnation of liver qi complicated by depression and anxiety, Qingnao Shuyu decoction can effectively reduce the frequency and duration of headache attacks, alleviate the severity of headache, and effectively improve depression and anxiety.

关 键 词：偏头痛伴抑郁焦虑 肝气郁结证 清脑舒郁汤 

分 类 号：R277.772[医药卫生—中医学]