小剂量阿司匹林合并华法林对心脏瓣膜置换术后患者的抗栓效果  

Study on the Effect of Low dose Aspirin Merger of Warfarin on Antithrombotic in Patients after Cardiac Valve Replacement

作　　者：方汉军 李锋华 许诚 

机构地区：[1]延安大学咸阳医院心脏外科,咸阳712000

出　　处：《血栓与止血学》2017年第6期939-941,944,共4页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的探讨小剂量阿司匹林合并华法林对心脏瓣膜置换术后患者的抗栓效果。方法以在我院2014年1月至2016年12月间接受心脏瓣膜置换术治疗的100例患者作为研究对象,根据不同的抗栓治疗方法,将其分为观察组(n=52)与对照组(n=48)。其中对照组患者使用华法林进行治疗,而观察组患者联合使用华法林与小剂量阿司匹林进行治疗。观察并比较两组患者的抗栓效果。结果观察组患者血栓栓塞发生率、抗凝相关出血发生率明显低于对照组(P<0.05)。结论在华法林基础上,给予心脏瓣膜置换术患者小剂量阿司匹林,能显著减少血栓形成及栓塞的发生,而且安全有效。Objective To study on the effect of low dose aspirin merger of warfarin on antithrombotic in patients after cardiac valve replacement. Methods The 100 patients treated with cardiac valve replacement in our hospital were considered as study objects and the clinical data were analyzed retrospectively. They were divided into observation group （n = 52 ）and control group （n = 48 ）according to different antithrombotie treatment. The patients were treated with warfarin in the control group, while the patients were treated with low dose aspirin based on warfarin in the observation group. The treatment effects were observed and compared. Results The incidence of thrombosis and Incidence of related bleeding in the observation group were significantly lower than that in the control group （ P 〈 0. 05 ）. Conclusion On the basis of warfarin, small dose aspirin is used for the patients with cardiac valve replacement, and it can significantly reduce thrombosis and embolism it is safe.

关 键 词：小剂量 阿司匹林 华法林 心脏瓣膜置换术 抗栓效果 

分 类 号：R542.5[医药卫生—心血管疾病]