白细胞介素-37抗炎及免疫调理作用研究进展  

The review of developments in the immunoregulation property and potential mechanism of interleukin -37

作　　者：刘航[1,2,3] 李为民 姚咏明[2] 

机构地区：[1]解放军第309医院肝胆外科,北京100091 [2]解放军总医院第一附属医院创伤研究中心,北京100048 [3]北京怀柔医院普外科,北京101400

出　　处：《中华实验外科杂志》2017年第11期1993-1996,共4页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金（81130035、81372054）;国家重点基础研究发展计划项目（2012CB518102）

摘　　要：白细胞介素（IL）-37是新近发现的IL-1家族成员。不同于其他IL-1家族成员，IL-37具有下调机体全身及局部炎性反应、调控机体免疫稳态等功能；IL-37的免疫抑制效应参与多种临床疾病过程，包括自身免疫性疾病、肿瘤及感染性疾病等，然而其确切抗炎作用机制仍未阐明。本文重点对IL-37的免疫功能的分子作用机制及其对免疫细胞功能的影响进行综述。Interleukin -37 （IL -37） is a new member of the IL - 1 family formerly referred to as IL - 1F7. Different from other IL - 1 family eytokine, IL - 37 can down - regulate both systemic and local inflammation, and mod- ulate the host immune response. The immunosuppressive property of IL - 37 has been demonstrated in many diseases, including the auto- immune disease,the cancer, and infectious diseases. Nevertheless, the precise mechanism underlying anti - inflammatory response of IL - 37 remains to be further elucidated. In this article, we briefly review the dis- eovery of IL - 37 especially its potential mechanism with regard to immune suppression secondary to various immune cells.

关 键 词：白细胞介素-37 炎性反应 免疫功能 免疫细胞 

分 类 号：R392[医药卫生—免疫学]