人诱导性多能干细胞的供体来源及其表观遗传学研究现状  

Current status of human induced pluripotent stem cell donor origin and its epigenetic research

作　　者：史桂东 周先虎[1] 冯世庆[1] 

机构地区：[1]天津医科大学总医院骨科,300052

出　　处：《中华实验外科杂志》2017年第11期2003-2006,共4页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金重点项目（81330042）;国家自然科学基金面上项目（81371957）;中俄合作项目标号（2014DFR31210）;天津科委支持重点项目（13RCGFSY19000,14ZCZDSY00044）

摘　　要：诱导性多能干细胞（iPS）是干细胞领域的研究热点，在组织工程学研究、自体细胞移植、药物研制和开发等诸多领域有着广泛应用前景。其具有类似胚胎干细胞（ES）的自我更新和多分化潜能，在体内外可以分化成多种成熟细胞，并且避免了胚胎干细胞在伦理道德制约、免疫排斥等方面的诸多问题。近年来再生医学的发展，尤其是干细胞技术的进步，iPS作为良好的＂种子细胞＂已成为国内外干细胞研究领域的前沿热点。随着iPS研究的不断深入以及临床实践的探索，其有望成为再生医学领域的一把利器。本文就iPS的人类供体细胞对比及表观遗传学方面进行综述。Induced pluripotent stem cells （iPS cells） are stem cell research focus areas, it has a broad appli- cation prospects in tissue engineering research, autologous cell transplantation, drug research and development and many other areas. Having self - renewal and multi - differentiation potential similar to embryonic stem cells, it can dif- ferentiate into more mature cells in vivo and in vitro, avoids the many problems in the ethical constraints, and other as- pects of immune rejection. In recent years, the development of regenerative medicine, in particular progress Stem Cell Technology, induced pluripotent stem cells as a good ＂seed cells＂ has become a domestic and international forefront of stem cell research hotspot. With the induction of new pluripotent stem cell research, deepening and exploring clinical practice, which is expected to become a tool in the field of regenerative medicine. This paper reviews the comparison of human donor cells and epigenetic aspects of induced pluripotent stem cells.

关 键 词：诱导性多能干细胞 供体细胞 表观遗传学 再生医学 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]