喹啉甲酸衍生物的合成与表征  

Synthesis and Characterization of Quinoline-4-carboxylic Acid Derivative

作　　者：张慧东[1] 张泽琦 修忠海 周璐[1] 

机构地区：[1]辽东学院化学工程学院,辽宁丹东118000

出　　处：《广东化工》2017年第22期42-43,54,共3页Guangdong Chemical Industry

基　　金：辽宁省自然基金项目(No.2014020172);辽宁省大型科学仪器共享服务平台能力建设项目(2016LD0112);辽东学院大学生创新创业训练项目

摘　　要：本文以靛红、乙酸酐为原料采用Friedlander-Pfitzinger法合成一种喹啉甲酸衍生物-2-氯-4-喹啉甲酸,用熔点、红外光谱、核磁氢谱对合成的产物进行结构表征,同时讨论了配料比、反应温度、反应时间等因素对收率的影响,确定最佳反应条件。In this paper, the isatin and acetic anhydride were used as raw materials by Friedlander-Pfitzinger synthesis of 2-chloroquninoline -4-carboxylic acid. The synthesized product was characterized by melting point, IR and 1H NMR spectroscopy. A study was carried out on the effect of the reaction time and temperature on the yield of the target product and the optimum reaction conditions were identified.

关 键 词：2-氯-4-喹啉甲酸 合成 表征 

分 类 号：TQ225.121[化学工程—有机化工]