215例湿热型强直性脊柱炎中药治疗数据挖掘及关联规则研究  

Data Mining Research and Association Rules Analysis on 215 Cases of Damp-heat Type Ankylosing Spondylitis Treated by Chinese Medicine

作　　者：黄旦 刘健[2] 忻凌[2] 张帆 宋倩 郭锦晨 周巧 

机构地区：[1]安徽中医药大学研究生院,合肥230038 [2]安徽中医药大学第一附属医院风湿科,合肥230031

出　　处：《中国中西医结合杂志》2017年第11期1325-1329,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家中医药重点学科中医痹病学建设项目(No.国中医药发[2009]30号);国家临床重点专科中医风湿病科建设项目(No.财社[2013]239号);国家自然基金青年项目(No.81403388);安徽省重点实验室建设项目(No.1306c083035);安徽省科技攻关项目(No.1604a0802085);安徽省自然基金项目(No.1508085QH159)

摘　　要：目的应用数据挖掘技术和关联规则分析安徽中医药大学第一附属医院风湿科中医论治湿热型强直性脊柱炎(AS)用药对患者免疫炎症及超氧化物歧化酶(SOD)指标的影响。方法基于数据挖掘技术,对安徽中医药大学第一附属医院风湿科215例2012年6月—2015年6月湿热型AS住院患者的病历资料进行回顾性研究。结合复杂网络技术挖掘其核心处方,并采用SPSS Clementine 12.0软件Aprior模块分析中药对免疫炎症及SOD指标的影响。结果 (1)对其中药处方进行分析,核心用药为:薏苡仁、陈皮、山药、茯苓、泽泻、蒲公英、白花蛇舌草、桃仁、红花、丹参、豨莶草、威灵仙、杜仲、狗脊、甘草。核心药物使用均在50%以上,其中以健脾药使用最多,药物以归脾、胃、肾经为主。(2)在关联规则最小置信度设为60%,最小支持度设为20%条件下提取值与指标关联较高的药对,山药配伍独活、黄柏分别与C3、C4关联度较高(置信度为85.19%,93.33%),与茯苓配伍与hs-CRP关联度高(置信度为78.10%);茯苓配伍知母与IgA、IgG关联度较高(置信度为83.33%,91.67%);黄柏配伍桃仁与ESR关联度较高(置信度为85.71%);豨莶草配伍蒲公英、独活分别与SOD、WBC关联度较高(置信度为85.71%,75.93%)。外用药芙蓉膏、消瘀接骨散与ESR、hs-CRP、SOD关联度较高。结论根据各用药的比例分析,本院风湿科治疗湿热型AS以从脾论治为主,兼顾肝肾,配伍祛风除湿、清热解毒、活血化瘀等药物的配方原则;并且中药内服及外用,与免疫炎症及SOD指标关联性高。Objective To analyze the effect of Chinese medicine used by department of rheuma- tology, the First Affiliated Hospital of Anhui University of Chinese Medicine on immune inflammatory bio- markers and superoxide dismutase （SOD） in treating damp-heat type ankylosing spondylitis （AS） pa- tients based on data mining technology and association rules analysis. Methods Data of damp-heat type AS hospitalized patients were retrospectively collected from June 2012 to June 2015 at department of rheumatology First Afficiated Hospital of Anhui University of Chinese Medicine, based on clinical data mining technology.The technology for complex networks was integrated to mine the core prescription. The effect on immune inflammatory biomarkers and SOD were analyzed by Aprior module in SPSS Clementine 12.0. Results （1） By analyzingthe herbal prescription, the core herbs of prescription were found as： Coix Seed, Pericarpium Citri Reticulatae, Rhizoma Dioscoreae, Poria Cocos, Rhizoma Alismatis, Herba Taraxaci, Oldenlandia, Semen Pruni Persicae, Flos Carthami, Salvia Miltiorrhiza, Herba Siegesbeckiae, Radix Clematidis, Cortex Eucommiae,Rhizoma Cibotii and Radix Glycyrrhizae . Those herbals took up o- ver 50% in core prescription. The most commonly used in treatment were Pi invigorating herbals, which mainly distributed to Pi, Wei or Shen channel. （2） Which could find some high-related couplet medicines under the condition that the minimum confidence level was set at 60% and the minimum support level 20%. Rhizoma Dioscoreae was high-related to C3, C4 when compatibility with Radix Angelicae Pubescer~ tis and Cortex Phellodendri （the confidence coefficients were 85.19% ,93.33% ）, and high-related to hs- CRP when compatibility with Poria Cocos （the confidence coefficient was 78.10% ）. Compatibility of Poria Cocos and Rhizoma Anemarrhenae was associated with IgA and IgG （the confidence coefficients were 83.33% ,91.67% ）, and compatibility of Cortex Phellodendri and Semen Pruni Persicae was associated with ESR

关 键 词：强直性脊柱炎 湿热型 关联规则 数据挖掘 免疫炎症 

分 类 号：R259[医药卫生—中西医结合]