新型坤净栓中呋喃唑酮溶出度的测定  

Determination of dissolution of furazolidone in new kunjing suppository

作　　者：刘杰 郭江涛 任娜[2] 吴伦[3] 田振坤[3] 

机构地区：[1]贵阳中医学院药学系,贵州贵阳550000 [2]山东大学淄博生物医药研究院,山东淄博255000 [3]黑龙江中医药大学药学院,黑龙江哈尔滨150040

出　　处：《化学工程师》2017年第11期26-28,共3页Chemical Engineer

基　　金：苗族医学研究协同创新中心-黔教合协同创新字[2015]05;国家工程技术研究中心组建项目2014FU125Q09;贵州省普通高等学校中药民族药(苗药)新剂型新制剂工程研究中心黔教合KY字[2014]22号;贵阳中医学院博士科研启动基金3043-043160012;3043-043160009

摘　　要：目的:建立紫外分光光度法测定新型坤净栓中呋喃唑酮体外溶出的方法。方法:选用桨法,以1.8%十二烷基硫酸钠为溶出介质,转速100r·min^(-1),温度37℃,检测波长340nm,采用紫外分光光度法对自制的3批新型坤净栓进行溶出度的测定,计算累积溶出率,并对各批次溶出度威布尔参数进行比较。结果:3批新型坤净栓溶出曲线的均一性良好。结论:表明新型坤净栓的制备工艺合理,质量可靠,建立的对新型坤净栓中呋喃唑酮溶出度测定的方法简便、快速、准确、可靠。Objective： To establish a UV method to determine the dissolution of furazolidone in new Kunjing suppository in vitro. Methods： Choosing oar method, with 1.8% SDS as the dissolution medium, the speed is 100r·min^-1, the temperature is 37℃, the detection wavelength is 340nm, using UV method to determine the dissolution of three batches of samples, calculating the cumulative dissolution rate and comparing the dissolution parameters in Weibull of each batch. Results： The results showed that the dissolution curve of uniformity of three batches of new Kunjing suppository is good. Conclusion： Showing that the preparation technology of new Kunjing suppository is reasonable, quality is reliable. The established method to determine the new Kunjing suppository dissolution is simple, rapid, accurate and reliable.

关 键 词：新型坤净栓 紫外分光光发 溶出度 

分 类 号：R944.23[医药卫生—药剂学]