复方青黛颗粒联合益生菌治疗溃疡性结肠炎的疗效观察  

Clinical effect of compound Qingdai granula combined with probiotics in treating ulcerative colitis

作　　者：陈铭诗[1] 杜立阳[1] 张杰[1] 

机构地区：[1]中国医科大学附属第一医院中医科,辽宁沈阳110001

出　　处：《中国中西医结合消化杂志》2017年第10期751-754,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：辽宁省自然科学基金资助项目(No:20092130)

摘　　要：[目的]观察复方青黛颗粒联合益生菌治疗溃疡性结肠炎临床疗效。[方法]将60例轻中度溃疡性结肠炎患者随机分为治疗组(32例)和对照组(28例),治疗组予以复方青黛颗粒联合治疗,对照组予以美沙拉嗪治疗,疗程1个月,随访12个月。观察2组临床症状、疾病活动度、便中菌群数量、结肠镜变化、不良反应及复发率。[结果]治疗组能有效改善临床症状、疾病活动度,调节肠道菌群,促进溃疡面愈合,且与对照组比较差异有统计学意义(P<0.05)。[结论]复方青黛颗粒联合能有效治疗溃疡性结肠炎,安全性高,复发率低。[Objective]To observe the therapeutic effect of compound Qingdai granula（CQG）combined with probiotics in treatment of patients with mild-moderate ulcerative colitis（UC）.[Methods]Sixty patients with mild-moderate UC were randomly divided into two groups.Thirty-two patients in study group were given CQG combined with Meichang＇an,and Twenty-eight patients in control group were given mesalazine,all patients were treated for one month and followed up for 12 months.To observe the two groups about the clinical symptoms,the disease activity score,the change of intestinal flora,the change of intestinal mucosa in coloscope,side effects and recurrence rate.[Results]The study group could effectively improve the clinical symptoms,reducing the disease activity score,maintain the balance of intestinal flora,healing of oral mucosal ulcer.There were a significant difference between the two groups（P0.05）.[Conclusion]The combined treatment with CQG and Meichang＇an is of better curative effect for UC and it could reduce the recurrence rate.

关 键 词：溃疡性结肠炎 复方青黛颗粒 益生菌 

分 类 号：R259[医药卫生—中西医结合]