苏州地区单中心6岁以下住院儿童急性呼吸道感染病毒病原分布特征研究  

Etiologic analysis of virus infection in hospitalized children with acute lower respiratory tract infection in Suzhou of China

作　　者：赵凯[1] 王玉杰[1] 胡剑[1] 包丽丽 

机构地区：[1]苏州市立医院本部儿科南京医科大学附属苏州医院本部儿科,江苏苏州215002

出　　处：《中国病毒病杂志》2017年第5期386-390,共5页Chinese Journal of Viral Diseases

摘　　要：目的分析苏州地区6岁以下住院儿童急性呼吸道感染(acute lower respiratory tract infection,ALRTI)病毒病原分布特征,为临床抗感染及疾病控制提供理论依据。方法以2011年1月至2016年12月在苏州市立医院本部儿科住院治疗的1 602例ALRTI患儿为研究对象,采用直接荧光免疫法对患儿鼻咽部上皮细胞进行呼吸道合胞病毒(RSV)、腺病毒(Adv)、流感病毒A(Flu A)和B(Flu B)、副流感病毒1~3(PIVⅠ、Ⅱ、Ⅲ)的检测对照。结果 1 602例ALRTI患儿的共1 602份标本中7种病毒阳性453份(28.28%),阳性率从高到低依次为RSV、PIV(PIVⅢ、PIVⅠ、PIVⅡ)、Flu(Flu A、Flu B)及Adv。不同性别病毒检测阳性率之间差异无统计学意义(P>0.05);不同季节和不同年份的病毒检测阳性率差异有统计学意义(P<0.05);不同年龄组病毒检测的总体阳性率、RSV阳性率两项的差异有统计学意义(P<0.05),余各项差异均无统计学意义。结论呼吸道病毒是本地区住院儿童ALRTI的常见主要病原之一,其分布存在年龄、季节和年份的差异,本地区以RSV、PIV(主要是PIVⅢ)为主。伴随年龄的增加,总体病毒和RSV感染的阳性率下降。病毒总体感染率以冬季最高,夏季最低;RSV以秋、冬季为主,PIV以春、夏季为主,Flu、Adv和混合感染均以冬季为主。Objective To analyze the pathogen distribution of virus infections in children under 6 years of age with acute lower respiratory tract infection（ALRTI）in Suzhou of China. Methods Children diagnosed with ALRTI in the Department of Pediatric inpatients in Suzhou Municipal Hospital from January 2011 to December 2016 were studied,and were tested for virus pathogens.Nasopharyngeal aspirates were obtained from children according to a standard protocol and were tested for respiratory syncytial virus（RSV）,adenovirus（Adv）,influenza A virus（Flu A）,influenza B virus（Flu B）,parainfluenza virusⅠ（PIV Ⅰ）,parainfluenza virusⅡ（PIV Ⅱ）;parainfluenza virusⅢ（PIV Ⅲ）with direct immunofluorescence assay. Results A total of 1 602 samples were detected,and 453 samples showed positive（28.28%）.The positive rates of RSV,PIV,Flu and Adv were 23.22%,4.68%,2.31% and 1.62%,respectively.The detection rates in ≤12 months,13-24 months and ≥25 months old group were 30.23%,25.27% and 9.78%,respectively（P〈0.05）. Conclusions Respiratory virus infection was common in children with acute lower respiratory tract infection in Suzhou of China.RSV and PIV were the major pathogens of ALRTI among hospitalized children in Suzhou,China.

关 键 词：急性下呼吸道感染 儿童 病毒 呼吸道合胞病毒 腺病毒 流感病毒 副流感病毒 直接免疫荧光法 

分 类 号：R446.6[医药卫生—诊断学] R725.6[医药卫生—临床医学]