转化生长因子β1基因多态性与我国乙型肝炎肝硬化相关性的Meta分析  

Correlation of TGF-β1 polymorphisms with cirrhosis after Hepatitis B infec-tion in China:a meta-analysis

作　　者：张琳 李世平[1] 赵典朋[1] 王蒙[1] 耿超[1] 

机构地区：[1]潍坊医学院附属医院肝胆胰外科,潍坊261000

出　　处：《中国癌症防治杂志》2017年第5期394-397,共4页CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT

摘　　要：目的探讨转化生长因子β1(transforming growth factor-β,TGF-β1)基因多态性与我国乙型肝炎肝硬化的相关性。方法检索Pub Med、Cochrane Library、EMbase、中国知识资源总库(CNKI)、中国生物医学文献数据库(CBM)和万方数据库(Wan Fang Data),筛选TGF-β1-509及-869位点基因多态性与我国乙型肝炎肝硬化的病例对照研究,应用Rev Man 5.3软件进行Meta分析。结果共纳入文献5篇,共586例乙型肝炎肝硬化患者,对照病例551例。Meta分析结果显示:FGF-β1-509位点基因型和-509位点T等位基因与乙型肝炎肝硬化均无相关性(OR=1.04,95%CI:0.79~1.36;OR=1.09,95%CI:0.92~1.28);FGF-β1-869位点基因型和-869位点C等位基因与乙型肝炎肝硬化亦无相关性(OR=1.61,95%CI:1.17~2.21;OR=1.02,95%CI:0.82~1.27)。结论 TGF-β1-509及-869位点基因型与等位基因均与我国乙型肝炎肝硬化无关联。Objective To meta-analyze the literature on possible correlation of TGF-β1 polymorphism with cirrhosis after Hepatitis B infection in China. Methods Relevant case-control studies were identified in PubMed,Cochrane Library,EMbase, CNKI,CBM,and WanFang databases,and data were meta-analyzed using RevMan 5.3. Results A total of five studies involving 586 cases were identified. Metaanalysis suggests that presence of cirrhosis after Hepatitis B infection is not significantly associated with the -509 genotype （OR = 1.04,95%Cl：0.79-1.36） ,the T allele at-509 （OR=1.09,95%Cl：0.92-1.28）,the T allele at-869 （0R=1.02,95%CI：0.82-1.27）,or the- 869 genotype （OR=1.61,95%CI： 1.17-2.21）. No significant publication bias was found. Conclusion Genotypes or alleles at the TGF-β1 polymorphisms-509 and -869 are not significantly associated with occurrence of cirrhosis after Hepatitis B infection in China.

关 键 词：转化生长因子Β1 基因多态性 乙型肝炎 肝硬化 META分析 

分 类 号：R575.2[医药卫生—消化系统]