白细胞介素-33在成人麻疹患者中的表达及意义  

The expression and role of interleukin-33 in patients with adult measles

作　　者：刘春华[1] 崔霞[1] 刘晶晶[1] 李庆彦[1] 崔燕平[1] 王思奎[1] 

机构地区：[1]山东省聊城市人民医院感染科,252000

出　　处：《国际流行病学传染病学杂志》2017年第5期317-320,共4页International Journal of Epidemiology and Infectious Disease

摘　　要：目的 探讨成人麻疹患者血清IL-33水平与临床生化及炎症指标的相关性.方法 选取成人麻疹并肝损害患者36例为麻疹肝损组,麻疹无肝损害患者28例为麻疹无肝损组,健康体检人群20例为健康对照组,于治疗前、治疗第7和第14天分别测定入组麻疹患者血清IL-33及主要肝功能指标及炎症指标.结果 治疗前,麻疹肝损组、麻疹无肝损组和健康对照组血清IL-33水平分别为（185.20＆#177;19.44） pg/mL、（168.70＆#177;18.14） pg/mL、（132.17＆#177;12.41） pg/mL,三组间差异有统计学意义（F=13.17,P＜0.05）;两组麻疹患者IL-33水平均显著高于对照组,差异有统计学意义（t=15.43、10.59,P＜0.05）.经治疗,麻疹肝损组患者不同检测时间点IL-33水平差异有统计学意义（F=10.82,P＜0.05）,逐步下降,至治疗第14天与健康对照组间差异无统计学意义（t=2.05,P＞0.05）.相关分析提示IL-33与ALT、γ谷氨酰氨基转移酶、IL-6呈正相关（r=0.332 8、0.200 3和0.597 2,P均＜0.01）.结论 血清IL-33在麻疹中高表达,其动态变化能够反映肝脏炎症的程度及转归.Objective To study the correlation between serum IL-33 and the indicators of clinical biochemistry and inflammation in patients with adult measles.Methods A total of 64 adult measles patients were selected and divided into acute liver damage group （n=36） and no liver damage group （n=28）.At the same time,20 healthy adults were selected as healthy controls.Venous blood samples were collected on the day of admission,the 7th day and 14th day after treatment.The IL-33 and main indicators of liver function and inflammation were analyzed.Results Before the treatment,the levels of IL-33 in acute liver damage group,no liver damage group and control group were （185.20＆#177; 19.44）pg/mL,（168.70＆#177;18.14） pg/mL and （132.17＆#177;12.41） pg/mL,respectively.The differences among three groups had statistical significance （F=13.17,P〈0.05）.The levels of IL-33 in two adult measles groups were obviously higher than that of control group,and the differences had statistical significance （t=15.43 and 10.59,P〈0.05）.After the treatment,IL-33 levels on different detection times in the acute liver damage group had significant difference （F=10.82,P〈0.05）.The level of IL-33 declined after 14-day treatment and there was no statistically significant difference between acute liver damage group and control group （t=2.05,P〉0.05）.Serum IL-33 levels in patients with liver damage showed positive correlation with levels of ALT,γ-glutamyltranspeptadase and IL-6 （r=0.338 2,0.200 3 and 0.597 2,Pall〈0.01）.Conclusions The serum IL-33 level has high expression in the measles complicated with liver damage,and its dynamic change reflects the severity and prognosis of liver inflammation.

关 键 词：麻疹 肝损害 血清IL-33 

分 类 号：R511.1[医药卫生—内科学]