依达拉奉对不停跳冠脉搭桥缺血-再灌注损伤的研究  

Observation on the protective effect of edaravone against the ischemia-reperfusion injury induced by coronary artery bypasses grafting on beating-heart

作　　者：魏国华[1] 鲁婷[1] 沈健[1] 倪燕[1] 

机构地区：[1]江苏省人民医院,220000

出　　处：《齐齐哈尔医学院学报》2017年第17期1985-1987,共3页Journal of Qiqihar Medical University

摘　　要：目的研究术前及术中应用依达拉奉对心肌缺血再灌注损伤的心肌保护作用。方法选取2015年6月至2016年1月于本院行不停跳冠脉搭桥手术患者100例,随机将其分为依达拉奉组和对照组各50例,抽取两组患者切皮(T1)、前降支再通后(T2)、术毕(T3)及术后24 h(T4)的动脉血,测定心肌损伤因子肌酸激酶MB同工酶(CK-MB)活性、心肌肌钙蛋白I(cTn I)浓度及氧化应激指标丙二醛(MDA)含量、超氧化物酶(SOD)及总抗氧化能力(TAOC),并进行统计分析。结果两组患者CK-MB含量、cTnI浓度在T4时,明显高于T1~T3时,差异有统计学意义(P<0.05);依达拉奉组患者T2~T4时cTnI、CK-MB水平均显著低于对照组患者,差异有统计学意义(P<0.05);依达拉奉组患者T2~T4时间点血清SOD及TAOC均高于对照组患者,而MDA水平显著低于对照组患者,差异有统计学意义(P<0.05)。结论依达拉奉可有效减轻不停跳冠脉搭桥手术过程中的心肌损伤,可明显改善氧化应激指标。Objective To study the cardio-protective effects of edaravone in patients with off-pump coronary artery grafting during perioperative and intra-operative period. Methods 100 patients underwent off-pump coronary artery bypass grafting in our hospital from June 2015 to Jan 2016 were included in this study,and were randomly allocated into experimental group（ edaravone group） and control group（ physiological saline group） with 50 cases in each group. Blood samples were taken from artery line before operation（ T1）,LIMA-LAD recanalization（ T2）,end of operation（ T3）,24 hour post-operation（ T4） to determine serum cTnI,CKMB,MDA,SOD,TAOC level. Results The serum CK-MB and cTnI were higher at T4 than those at T1-T3 in both groups（ P〈0. 05）. The serum cTnI,CK-MB and MDA in experimental group were lower than those in control group at T2-T4,while SOD and TAOC higher than control group（ P〈0. 05）. Conclusions Edaravone can effectively alleviate the reperfusion injury of myocardial infarction with off-pump coronary artery bypass grafting,and it can significantly improve the oxidative stress indexes of patients.

关 键 词：再灌注损伤 依达拉奉 不停跳冠脉搭桥术 心肌保护 

分 类 号：R654.2[医药卫生—外科学]