尾加压素Ⅱ水平与冠状动脉慢血流现象关系的研究  

Study on the relationship between coronary slow flow phenomenon and urotensin-Ⅱ

作　　者：关欣[1] 白志生[1] 

机构地区：[1]宝鸡市人民医院心血管内科,721000

出　　处：《心肺血管病杂志》2017年第10期815-819,共5页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:探讨尾加压素Ⅱ(UⅡ)水平与冠状动脉慢血流(CSF)现象的关系。方法:选择2010年1月至2014年12月间,来我院接受检测确诊的CSF患者40例(CSF组,n=40),另选择同期冠状动脉血流速度正常患者40例作为对照组(对照组,n=40)。冠状动脉血流速度的评价采用TIMI血流计帧法进行,血清UⅡ水平利用人UⅡ ELISA试剂盒采用酶联免疫吸附测定法(ELISA)测定,比较两组患者之间临床特征、生化指标及血液学指标差异。并应用多因素非条件Logistic回归分析影响CSF发生的危险因素。结果:两组患者在性别、年龄、糖尿病史、高血压、高脂血症、吸烟史、收缩压、舒张压、药物使用(血管紧张素转化酶抑制剂、血管紧张素Ⅱ受体阻断剂、β-受体阻滞剂、钙通道阻滞剂、阿司匹林、他汀类药物、噻吩并吡啶)方面,差异无统计学意义。两组患者在空腹血糖、血肌酐、TC、TG、C-LDL、AGB方面差异无统计学意义;在白细胞、血清UⅡ、C反应蛋白(CRP)水平方面差异有统计意义(P<0.05),其中CSF组白细胞水平、血清UⅡ水平、CRP水平显著高于对照组,CSF组C-HDL水平显著低于对照组。CSF患者血清UⅡ水平与收缩压、舒张压、空腹血糖、血肌酐、TC、TG、C-LDL、C-HDL、血红蛋白无相关性(P>0.05),与帧计数、白细胞水平、CRP水平呈正相关(P<0.05)。经多因素Logistic回归分析结果显示,CRP水平升高、血清UⅡ水平升高、白细胞水平升高是CSF发生的危险性因素(P<0.05)。结论:CSF患者中血清UⅡ水平显著高于非CSF患者,提示血清UⅡ水平是CSF的影响因素。Objective： To investigate the relationship between II （UII） level and coronary slow flow （CSF）. Methods： 40 patients with CSF in our hospital from Jan 2010 to Dec 2014 were selected as study subjects, another 40 patients with normal coronary blood flow velocity were selected as control group. Evaluation of coronary flow velocity of blood flow by using TIMI frame count method , the serum level of UII by using UII ELISA kit using enzyme-linked immunosorbent assay （ELISA） ,the clinical features, biochemical indexes and hematological indexes were compared between the two groups. Multivariate unconditional Logistic regression was used to analyze the risk factors of CSF. Results ： There was no significant difference in two groups of patients with gender, age, history of diabetes, hypertension, hyperlipidemia, smoking, systolic blood pressure, dias- tolic blood pressure, drug use （ angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, beta blockers, calcium channel blockers, aspirin, statins, thienopyridine）（P 〉 0. 05）. The two groups had no sig- nificant difference in fasting blood glucose, serum creatinine,TC, TG, C-LDL, hemoglobin （P 〉 0.05）, signif- icant differences in white blood cells, serum UII,C reactive protein（ CRP,P 〈0.05 ）, in CSF group, levels of white blood cells, the serum level of UII and CRP was significantly higher than the control group, the level of C- HDL in CSF group was significantly lower than that in control group. The level of serum UII in patients with CSF was not correlated with systolic and diastolic blood pressure, fasting blood glucose, serum creatinine, TC, TG, C-LDL, C-HDL and hemoglobin （ P 〉 0. 05 ）, and positively correlated with frame count, the level of white blood ceils and CRP （ P 〈 0.05 ）. The result of multiple Logistic regression analysis showed that CRP, serum UII level and white blood cell level were the risk factors of CSF （ P 〈 0. 05 ）. Conclusion： Serum UII levels were found to be significan

关 键 词：尾加压素II 冠状动脉慢血流 冠状动脉造影 心肌梗死溶栓帧数计数 

分 类 号：R54[医药卫生—心血管疾病]