丙基硫氧嘧啶致相关性小血管炎118例文献分析  

Literature Analysis of 118 Cases of Propylthiouracil-associated Small Vasculitis

作　　者：田晓江[1,2] 唐学文[1,2] 季欢欢[2] 贾运涛[2] 

机构地区：[1]重庆医科大学药学院,重庆400016 [2]重庆医科大学附属儿童医院/儿童发育疾病研究教育部重点实验室/儿童发育重大疾病国家国际科技合作基地/儿科学重庆市重点实验室,重庆400014

出　　处：《中国药房》2017年第33期4644-4647,共4页China Pharmacy

基　　金：重庆市卫生计生委医学科研项目(No.2016ZDXM017);重庆市社会民生科技创新专项(No.cstc2016shmszx130048)

摘　　要：目的:探讨丙基硫氧嘧啶(PTU)诱发相关性小血管炎(ASV)的一般规律及特点,为临床合理用药提供参考。方法:检索1990-2016年发表的PTU诱发ASV不良反应/不良事件的个案报告,并就收集到的118例ADR相关信息进行统计和分析。结果:PTU诱发ASV女性发生率较高,且以18~59岁最高;87例患者用药剂量在600 mg/d内,用药后1~5年发生率较高;临床表现以肾、肺系统损害较多;所有患者停药后59例行激素治疗,30例行激素联合免疫抑制剂治疗;115例患者预后良好,3例死亡。结论:对使用PTU的患者除定期筛查抗中性粒细胞胞浆抗体外,还应定期评估其不良反应症状,以减少或避免严重不良反应的发生。OBJECTIVE： To investigate the general regularity and characteristics of propylthiouraeil （PTU）-associated small vasculitis （ASV）, and to provide reference for rational drug use in the clinic. METHODS： ADR/ADE ease reports of PTU-ASV published during 1990-2016 were retrieved. The data of 118 ADR cases were analyzed statistically. RESULTS： The incidence of PTU-ASV was higher in female and was highest in 18-59 age group. Drug dose of 87 patients were within 600 mg/d, and the inci- dence of PTU-ASV was the highest within 1-5 years after medication. Main clinical manifestations were renal and lung function in- jury. After drug withdrawal, 59 patients received hormone therapy, and 30 patients received hormone combined immunosuppressive agent. Finally, 115 patients were recovered and 3 patients died. CONCLUSIONS： In older to reduce or avoid the occurrence of ADR, it is necessary to regularly check antineutrophil cytoplasmic antibody related indexes and evaluate the symptoms of ADR.

关 键 词：丙基硫氧嘧啶 相关性小血管炎 不良反应 文献分析 

分 类 号：R979.9[医药卫生—药品]