氧化响应材料及其纳米粒的制备  

Oxidation-Responsive Polymers: Them Nanoparticles Preparation

作　　者：张世倡 温露[2] 陈钢[2] 

机构地区：[1]南方医科大学顺德医院附属杏坛医院,广东佛山528300 [2]广东药科大学药科学院,广东广州510000

出　　处：《广东化工》2017年第21期116-118,共3页Guangdong Chemical Industry

摘　　要：疾病是人类不可避免的一种生理状态,许多研究表明在疾病条件下,机体内的活性氧含量会有一定程度的提高,如何利用机体这一特性去治疗机体的疾病成为了许多科学研究者的关注热点。在氧化条件下,多聚物会发生剧烈的物理变化,如溶解或交联。在一定程度下这种响应能被用于调节药物的释放动力学,增强药物效应。本文主要介绍几种氧化响应材料的结构特征及其纳米粒的制备方法,简单说明其作用机理及结构与性能的联系,并展望这类型聚合物的应用前景。Disease is a kind of inevitable physiological state, many studies have shown that the reactive oxygen species will increase when you are sickness, how to use that properties to treat the body become a hot topic of scientist. Polymers will dramatic change under oxidation, for example, dissolve or cross-link in the solution which can be used to regulate the release kinetics of drugs and enhance the treat effect. This paper mainly introduces several oxidation responsive materials, structure characteristics and preparation of nanoparticles, explain the mechanism, after that look forward to the future of application.

关 键 词：氧化响应 载体材料 纳米粒 机制 

分 类 号：TQ[化学工程]