CYP1A1 rs4646903基因多态性与慢性阻塞性肺疾病易感性的Meta分析  

Association between CYP1A1 rs4646903 polymorphisms and chronic obstructive pulmonary disease:a meta-analysis

作　　者：索生红[1] 曹生海[2] 

机构地区：[1]青海卫生职业技术学院,青海西宁810000 [2]青海省中医院呼吸科,青海西宁810000

出　　处：《中国呼吸与危重监护杂志》2017年第6期555-560,共6页Chinese Journal of Respiratory and Critical Care Medicine

摘　　要：目的 分析细胞色素氧化酶P450(CYP)酶系中CYP1A1 rs4646903基因多态性与慢性阻塞性肺疾病(简称慢阻肺)易感性的关联强度。方法 检索CNKI数据库、VIP数据库、WanFang数据库、PubMed数据库、Cochrane图书馆及Embase数据库,检索时限从建库开始至2016年1月。査找CYP1A1 rs4646903基因多态性与慢阻肺易感性相关的病例对照研究。采用StataSE 12.0进行数据分析。应用比值比(OR)及其95%可信区间(95%CI)表示其关联强度。结果 共纳入病例对照研究6项,涉及患者1 050例,健康对照1 202例。Meta分析结果显示:累加遗传模型(CC vs.TT,OR=1.63,95%CI 1.17~2.27,P=0.004)、隐性遗传模型(CC vs.TC+TT,OR=1.62,95%CI1.19~2.20,P=0.002)可能是慢阻肺的遗传易感因素。而等位基因模型(Cvs.T,OR=1.20,95%CI0.95~1.51,P=0.118)、显性遗传模型(CC+TC vs.TT,OR=1.19,95%CI 0.82~1.72,P=0.366)可能不会增加慢阻肺的罹患风险。结论 CYP1A1rs4646903基因多态性与慢阻肺易感性相关,且为慢阻肺的危险因素,但还需更多大样本的研究进一步证实。Objective To summarize the association between CYP1A1 rs4646903 polymorphisms and COPD risk. Methods Systematic literature search was conducted （up to January 2016） in five online databases, ie. PubMed, Embase, China National Knowledge Infrastructure （CNKI）, VIP database, and WanFang databases. The strength of association was calculated by odds ratio （OR） and corresponding 95% confidence interval （CI）. Results Six case-control studies with 1 050 cases and 1 202 controls were included. This study suggested a significant association between the CYP1A1 rs4646903 polymorphism and COPD risk （CC vs. TT： OR=1.63, 95%CI 1.17-2.27, P=0.004; CC vs. TC＋TT： OR=1.62, 95%CI 1.19-2.20, P=0.002）. However, there was no significant difference between allele model （C vs. T, OR=1.20, 95%CI 0.95-1.51, P=0.118） and dominant model （CC＋TC vs. TT, OR=1.19, 95%CI 0.82-1.72, P=0.366）. Conclusions The CYP1A1 rs4646903 polymorphisms might alter the susceptibility of COPD. More well-designed studies with larger sample size are warranted.

关 键 词：慢性阻塞性肺疾病 细胞色素氧化酶P450 CYP1A1 基因多态性 META分析 

分 类 号：R563.9[医药卫生—呼吸系统]