疏肝宁胃汤联合奥美拉唑治疗慢性浅表性胃炎临床研究  

Clinical Study of Shugan Ningwei Decoction Combined with Omeprazole in Treatment of Chronic Superficial Gastritis

作　　者：魏晏[1] 魏明[2] 

机构地区：[1]河南中医药大学第三附属医院,河南郑州450008 [2]河南中医药大学第一附属医院,河南郑州450000

出　　处：《中医学报》2017年第11期2204-2207,共4页Acta Chinese Medicine

基　　金：河南省科技攻关项目(112102310112)

摘　　要：目的:观察疏肝宁胃汤联合奥美拉唑治疗慢性浅表性胃炎的临床疗效。方法:将116例慢性浅表性胃炎患者按随机数表法随机分为观察组和对照组,每组58例。两组患者均给予健康教育。对照组采用奥美拉唑治疗;观察组在对照组治疗基础上加用疏肝宁胃汤治疗,方药组成:白芍20 g,生黄芪20 g,蒲公英20 g,枳壳15 g,党参15 g,半夏15 g,当归15 g,茯苓15 g,延胡索10 g,甘草6 g,三七粉3 g。两组患者均连续治疗1个月。治疗后观察两组患者的临床疗效、病理疗效和不良反应发生情况。比较两组患者治疗前后中医症状积分变化情况,检测两组患者治疗前后血清环氧化酶-2(Cyclooxygenase-2,COX-2)和胃泌素(gastrin,Gas)水平。结果:治疗后,对照组的病理疗效有效率为75.9%,观察组的病理疗效有效率为96.6%,两组比较,差异有统计学差异(P<0.05);治疗后,对照组临床疗效有效率为72.4%,观察组有效率为94.9%,两组比较,差异有统计学意义(P<0.05);症状积分统计结果显示,观察组在反酸嗳气、消化不良、胃脘疼痛及食欲不振的减少值明显高于对照组,差异有统计学意义(P<0.05);两组患者不良反应比较,腹胀胃痛:对照组出现3例,观察组出现2例。头晕恶心:对照组出现4例,观察组出现1例。脏器功能损伤并发症:对照组出现1例,观察组未出现。对照组不良反应发生率为13.8%,观察组不良反应发生率为5.1%,两组比较,差异有统计学意义(P<0.05);两组患者治疗后血清中COX-2和Gas水平明显低于治疗前,观察组治疗后血清中COX-2和Gas水平明显低于对照组,差异有统计学意义(P<0.01)。结论:疏肝宁胃汤联合奥美拉唑合治疗慢性浅表性胃炎患者能有效提高临床疗效及病理疗效,改善患者临床症状和实验室指标,同时降低不良反应发生率。Objective： To observe the clinical effect of Shugan Ningwei Decoction combined with Omeprazole in treatment of Chronic superficial gastritis. Methods： 116 patients with chronic superficial gastritis were randomly divided into observation group and control group,with 58 cases in each group. Both groups were given health education. The control group was treated with omeprazole.The observation group was treated with Shugan Ningwei Decoction in addition to the treatment of the control group. The composition of the prescription is the following： White peony root 20 g,Raw Radix Astragalis 20 g,Dandelion 20 g,fructus aurantii 15 g,Codonopsis pilosula 15 g,Pinellia 15 g,Angelica 15 g,Poria 15 g,Corydalis 10 g,Licorice 6 g,Radix notoginseng powder 3 g. Two groups of patients were treated for 1 month. After treatment,the clinical efficacy,pathological curative effect and adverse reaction were observed. The levels of serum cyclooxygenase-2（ COX-2） and gastrin（ Gas） were measured before and after treatment in both groups before and after treatment. Results： After treatment,the pathologic effective rate of the control group was 75. 9%. The pathologic effective rate of the observation group was 96. 6%. There was significant difference between the two groups（ P〈0. 05）. After treatment,the effective rate of clinical efficacy in the control group was 72. 4% and that was 94. 9% in the observation group. The difference was statistically significant（ P〈0. 05）. The results of symptom score suggested that the reduction of acid reflux,dyspepsia,epigastric pain and loss of appetite in the observation group was significantly higher than that in the control group（ P〈0. 05）.The adverse reactions of the two groups of patients are as follows： Abdominal pain： There were 3 cases in the control group and 2 cases in the observation group. Dizziness nausea： There were 4 cases in the control group and 1 case in the observation group. The complication of the organ dysfunction： 1 case was found in the contro

关 键 词：慢性浅表性胃炎 疏肝宁胃汤 奥美拉唑 血清环氧化酶-2 胃泌素 中医药疗法 中西医结合 

分 类 号：R259.733.1[医药卫生—中西医结合]