乌梅丸加减对溃疡性结肠炎患者炎性因子的影响  

Clinical Study on Modified Wumei Pills in Treatment of Ulcerative Colitis and its Effect on Inflammatory Factors

作　　者：魏文先 翟玉云 邹颖[2] 

机构地区：[1]胶州市人民医院,山东胶州266300 [2]南方医科大学,广东广州510000

出　　处：《中医学报》2017年第11期2208-2211,共4页Acta Chinese Medicine

基　　金：国家自然科学基金(30772701)

摘　　要：目的:观察乌梅丸加减治疗溃疡性结肠炎的临床疗效以及体内炎性因子的变化情况。方法:将68例溃疡性结肠炎患者按照随机数字法分为治疗组和对照组,每组34例。对照组采用泼尼松治疗;治疗组在对照组基础上加用乌梅丸加减治疗,其配方组成:乌梅、炒白术、炒白芍、地瑜各15g,干姜、黄连、党参、桂枝各10 g,附子、当归各5 g,三七(粉)3 g,每日1剂,7 d为1个疗程,共治疗4个疗程。两组患者均连续给药1个疗程(28 d)。治疗后比较两组患者临床疗效、血清炎性因子变化,并观察两组患者肠道菌群变化。结果:两组患者临床疗效比较,治疗组有效率为91.18%,对照组有效率为73.53%,两组比较,差异有统计学意义(P<0.05)。两组患者治疗前肿瘤坏死因子-α(tumor necrosis factor alpha,TNF-α)、白细胞介素-4(Interleukin-4,IL-4)、白细胞介素-8(Interleukin-8,IL-8)、白细胞介素-10(Interleukin-10,IL-10)水平比较,差异无统计学差异(P>0.05)。两组患者治疗后较治疗前相比IL-4水平、IL-10水平升高,IL-8及TNF-α水平降低,治疗组与对照组比较IL-4、IL-8、IL-10、TNF-α改善更加显著,差异有统计学意义(P<0.05)。两组患者治疗前双歧杆菌、乳酸菌、大肠杆菌水平比较,差异无统计学差异(P>0.05);两组患者治疗后与治疗前比较,双歧杆菌、乳酸菌升高,大肠杆菌降低,差异有统计学意义(P<0.05)。结论:乌梅丸加减能提高溃疡性结肠炎的临床疗效,改善了血清中炎性因子的水平,改善肠道菌群中各细菌的水平,提高有益菌的水平。Objective： To observe the clinical curative effect and the changes of inflammatory factors in treatment of ulcerative colitis. Methods： Sixty-eight patients with ulcerative colitis were randomly divided into treatment group and control group. The control group was treated with prednisone. The treatment group was treated with Wumei Pills in addition to that of the control group. The composition of the formula was： Wu Mei 15 g,Atractylodes macrocephala 15 g,Fried white peony root 15 g,Warthworm 15 g,Ginger 10 g,Berberine 10 g,codonopsis 10 g,Guizhi 10 g,aconite 5 g,Angelica 5 g,Sanqi 3 g. Seven days was a course of treatment,and there were a total of 4 courses of treatment. The clinical efficacy,the changes of serum inflammatory factors and the changes of intestinal microflora of two groups of patients were observed and analyzed. Results： The effective rate of the two groupsin the treatment group was 91. 18% and that of the control group was 73. 53%. The difference was statistically significant（ P〈0. 05）. There was no significant difference in the levels of tumor necrosis factor alpha（ TNF-α）,interleukin-4（ IL-4）,interleukin-8（ IL-8） and interleukin-8（ IL-8） and interleukin-10（ IL-10） between the two groups before treatment（ P〈0. 05）. The levels of IL-4 and IL-10 increased in both groups compared with those before treatment,IL-8 and IL-10 decreased in the treatment group compared with those of the control group,and TNF-α improved more significantly,the difference was statistically significant（ P〈0. 05）. There was no significant difference in the two groups in the levels of Bifidobacterium,Lactobacillus and Escherichia coli（ P〈0. 05）.Compared with the two groups before treatment,Bifidobacterium and Lactobacillus increased,and the difference was statistically significant（ P〈0. 05）. Conclusion： Wumei Pills can improve the clinical curative effect of ulcerative colitis,improve the level of inflammatory factors in serum,improve the level of bacteria in intest

关 键 词：溃疡性结肠炎 乌梅丸 泼尼松 中医药疗法 中西医结合 

分 类 号：R269.741[医药卫生—中西医结合]