银屑病患者血清C3的表达及其与银屑病的相关性  

The expression of serum C3 in the patients with psoriasis and the correlation between C3 and psoriasis

作　　者：孙祖凤[1] 罗阳[1] 韩悦[1] 高迎霞[1] 周敏[1] 温志华[1] 顾宁琰[1] 陈京京[1] 朱虹[1] 姚煦[1] 刘军[2] SUN Zufeng;LUO Yang;HAN Yue;GAO Yingxia;ZHOU Min;WEN Zhihua;GU Ningyan;CHEN Jingjing;ZHU Hong;YAO Xu;LIU Jun(Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China;Department of Dermatology, the Affiliated Drumtower Hospital of Nanjing University, Nanjing 210008, China)

机构地区：[1]中国医学科学院皮肤病研究所,江苏南京210042 [2]南京大学医学院附属鼓楼医院,江苏南京210008

出　　处：《中国麻风皮肤病杂志》2017年第10期599-602,共4页China Journal of Leprosy and Skin Diseases

基　　金：国家自然科学基金(编号:81371735;81573045);江苏省自然科学基金(编号:BK20150166)

摘　　要：目的:明确银屑病患者血清C3与银屑病发生及代谢紊乱的相关性。方法:收集63例未系统治疗的寻常型银屑病患者(体重正常或偏瘦者30例,超重或肥胖者33例)及健康对照30名,t检验分析体重正常或偏瘦的银屑病患者血清C3与正常对照组间的差异,pearson或spermen相关性分析银屑病患者血清C3与体重指数、PASI评分、血脂、血糖、血压及代谢综合征的之间的相关性。结果:超重或肥胖的银屑病患者,体重正常或偏瘦的银屑病患者及健康对照中血清C3水平分别为1.37±0.21g/L,1.12±0.14 g/L,1.07±0.10 g/L。银屑病患者血清C3水平与体重指数、PASI评分、甘油三脂、及代谢综合征的发生显著正相关(均P<0.05),与高密度脂蛋白水平显著负相关(P<0.05)。结论:血清C3可能与银屑病的发生及代谢紊乱相关。Objective： To determine the correlation between the level of serum complement 3（ C3） and metabolic disorder in the patients with psoriasis. Methods： Sixty-three patients with psoriasis vulgaris without systematic treatment（ 30 cases with normal or lower body weight and 33 cases with overweight body weight or obesity） and 30 healthy controls were enrolled into this study. The difference in the levels of serum C3 between the patients with normal or lower body weight and healthy controls was analyzed by T test. The relationship between C3 level and Body Mass Index,PASI score,blood lipid,blood glucose,blood pressure and metabolic syndrome in the patients was analyzed by Pearson＇s test or Spermen＇s test. Results： The levels of serum C3 in the patients with overweight body weight or obesity,normal or lower body weight and healthy controls were1.37±0.21 g/L,1.12±0.14 g/L and 1.07±0.10 g/L. The levels of C3 in the patients with psoriasis was positively correlated with body mass index,PASI score,triglyceride,and metabolic syndrome（ P〈0. 05）,and negatively correlated with HDL（ P〈0. 05）. Conclusion： C3 level may be associated with the occurrence of psoriasis and metabolic disorders in the patients with psoriasis.

关 键 词：银屑病 C3 代谢综合征 体重指数 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]