microRNA在糖尿病肾病小管间质纤维化中的作用  

microRNA on renal tubular interstitial fibrosis in diabetic nephropathy

作　　者：谢沂均 张倩[1] 薛耀明[1] 

机构地区：[1]南方医科大学南方医院内分泌代谢科,广州510515

出　　处：《肾脏病与透析肾移植杂志》2017年第5期457-461,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：糖尿病肾病是糖尿病一个主要的微血管病变,临床上以持续白蛋白尿和(或)肾小球滤过率进行性下降为主要特征。研究发现,肾小管间质病变与糖尿病相关慢性肾脏病肾脏功能恶化的相关性较肾小球病变更为密切。microRNA(miRNA)是生物小分子,已成为糖尿病肾病研究领域的新方向,被证实与糖尿病肾病的发生、发展相关,miRNA参与肾小管间质纤维化,导致肾小管结构改变和功能障碍。本文就miRNA参与糖尿病肾病肾小管病理生理过程作用机制的作一综述。Diabetic kidney disease is a major microvascular complication in diabetes,and the clinical features is persistent proteinuria and（ or） decline of glomerular filtration rate. It was found that compared to glomerular disease,the correlation between renal tubular injury and renal function deterioration of diabetic kidney disease is higher. microRNA（ miRNA） is a group of short noncoding RNAs,which has become a new direction in the research field of diabetic kidney disease,and it has been proved to be related to the occurrence and development of diabetic kidney disease. miRNA is involved in tubule-interstitial fibrosis,leading to renal tubular injury and dysfunction. The purpose of this review is to summarize the research achievements about the mechanism of miRNA involved in the pathological and physiological processes of diabetic kidney disease.

关 键 词：糖尿病肾病 MICRORNA 肾小管间质纤维化 细胞外囊泡 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]