对氧磷酶-1酶活性在子宫内膜异位症诊断及分期中的价值  

The value of PON1 activity on the diagnosis and staging of endometriosis

作　　者：龚婷[1] 张元珍[1] Gong Ting;Zhang Yuanzhen.(Zhongnan Hospital of Wuhan University, Wuhan 430071)

机构地区：[1]武汉大学中南医院,武汉430071

出　　处：《现代妇产科进展》2017年第11期816-818,共3页Progress in Obstetrics and Gynecology

基　　金：国家自然科学基金资助项目(No:81370707)

摘　　要：目的:探讨子宫内膜异位症(EMs)患者外周血对氧磷酶-1(PON1)酶活性作为疾病诊断及其病情严重程度的指标的可能性。方法:选取近16年EMs患者外周血PON1酶活性测定的相关文献进行Meta分析。比较其在EMs和非EMs良性病变育龄期妇女外周血中,以及其在不同EMs分期患者外周血中的差异。结果:EMs患者外周血中PON1酶活性较非EMs良性病变女性显著降低(OR=-51.27,95%CI为-72.52^-30.02,P<0.05),Ⅲ~Ⅳ期明显低于Ⅰ~Ⅱ期(OR=-45.31,95%CI为-60.47^-30.20,P<0.05)。结论:PON1活性与EMs发生、发展密切相关,测定患者血PON1酶活性可作为EMs诊断、分期的血清学指标。Objective ：To investigate the probability of Paraoxonase-1 （PON1） activity in peripheral blood as an indicator of diagnosis and staging determination of endometriosis. Methods：The study enrolled the literatures about PONI activity detection in peripheral blood of patients with endometriosis in recent sixteen years. The differences of PON1 activity in peripher- al blood of patients with endometriosis and other benign lesions women of childbearing age and PON1 activity in peripheral blood of patients with endometriosis of different stages were com- pared. Results：PON1 activity in peripheral blood of patients with endometriosis was significant- ly lower than benign lesions women of childbearing age （ OR =-51.27,95 % CI：-72.52 - -30. 02 ,P〈0.05 ）. PON1 activity in peripheral blood of patients with endometriosis of stage Ⅲ -Ⅳ was significantly lower than patients with endometriosis of stage Ⅰ - Ⅱ （ OR = -45.31,95 % CI： -60.47 - -30.20, P〈0.05 ）. Conclusion： PON1 activity is closely correlated with occurrence and development of endometriosis, PON1 activity detection in peripheral blood has a certain sig- nificance in diagnosis, staging of endometriosis.

关 键 词：子宫内膜异位症 PON1酶活性 氧化应激 诊断 分期 血清学指标 

分 类 号：R71[医药卫生—妇产科学]