维生素C在脓毒症中的应用进展  

Advancement in the application of vitamin C in sepsis

作　　者：王飞飞 朱晓萍[2] 马少林[1] 

机构地区：[1]同济大学附属东方医院中心ICU,上海200120 [2]同济大学附属东方医院呼吸内科,上海200120

出　　处：《中国急救医学》2017年第11期988-991,共4页Chinese Journal of Critical Care Medicine

摘　　要：脓毒症常引发机体微循环障碍、组织低氧和器官衰竭，严重威胁人类健康。近年来大量研究显示，脓毒症患者的多种病理生理改变与氧化应激明显相关，具有抗氧化作用的维生素C（Vit C）对改善脓毒症患者的病情具有多重效应，能改善患者的预后。本文回顾性分析了目前VitC改善脓毒症患者病情的机制及其在临床中应用的相关研究，旨在对脓毒症患者及时实施临床有效的干预措施，改善脓毒症患者的预后。Sepsis severely threat human health which impaired the microcirculation, tissue hypoxia and multiple organ failure. In recent years, a growing body of research has shown that pathophysiological changes in patients with sepsis associated with oxidative stress. The effect of antioxidant supplementation with vitamin C for improving the condition of patients with sepsis with multiple effect, can improve the prognosis of patients. This article reviews the related researches of mechanism and the clinical applications of vitamin C in septic patients in order to timely implement an effective intervention measures for septic patients to improve survival rate.

关 键 词：维生素C(Vit C) 抗坏血酸 脓毒症 氧化应激 

分 类 号：R572[医药卫生—消化系统]