1型糖尿病的免疫机制研究进展  

Immune mechanism research of type 1 diabetes mellitus

作　　者：陈国军[1] 杨中汉[2] 冯娟[3] 

机构地区：[1]广东省佛山市第一人民医院急诊科,广东佛山528000 [2]中山大学中山医学院,广东广州510080 [3]佛山科学技术学院口腔医学院,广东佛山528000

出　　处：《中国医药导报》2017年第32期39-42,共4页China Medical Herald

基　　金：广东省科技计划项目(2016A020214001)

摘　　要：1型糖尿病(T1DM)是具有遗传倾向的自身免疫性疾病,发病率逐年递增,其发病机制较为复杂且尚未完全阐明,涉及到T淋巴细胞和多种固有免疫细胞的相互调控。免疫细胞攻击胰岛β-细胞使其损伤或减少被认为是T1DM的主要致病因素。目前的治疗方法也有各自的局限,包括传统的胰岛素注射、胰岛移植,以及近年来的免疫治疗和干细胞治疗等方法。随着对T1DM发病机制的深入研究,将为T1DM的防治提供更为有效的靶点和方法。Type 1 diabetes mellitus （T1DM） is a kind of autoimmune disease with genetic predisposition and its incidence is gradually increasing. The pathogenesis is relatively complicated and not yet fully elucidated. It relates the mutual regulation of T lymphocytes and a variety of innate immune ceils. Immune cells attack the islet beta cells reduce its damage which is regarded as a main pathogenic factor of T1DM. The current treatments of TIDM, including traditional insulin injection, islet transplantation, immunotherapy and stem cell therapy of recent years or other methods, have the limitation. With the further study of the pathogenesis of T1DM, more effective targets and methods will be provided.

关 键 词：1型糖尿病 胰岛Β-细胞 淋巴细胞 固有免疫细胞 

分 类 号：R58[医药卫生—内分泌]