经皮冠状动脉介入治疗在缺血性心肌病中的应用价值  

Application value of percutaneous coronary intervention in ischemic cardiomyopathy

作　　者：田家齐[1] 李金矿[2] 

机构地区：[1]湖北省钟祥市人民医院心内科,湖北钟祥431900 [2]湖北省钟祥市人民医院放射科,湖北钟祥431900

出　　处：《中国医药导报》2017年第32期51-54,共4页China Medical Herald

基　　金：湖北省卫生计生委科研立项项目(WJ2017F100)

摘　　要：目的探究经皮冠状动脉介入治疗(PCI)在缺血性心肌病治疗中的应用价值。方法选择2014年2月~2015年4月湖北省钟祥市人民医院收治的缺血性心肌病患者96例,根据随机抛硬币法将其分为两组,每组各48例。对照组接受基础药物治疗,观察组在此基础上予以PCI治疗。比较两组治疗后生化指标、心功能情况以及随访期间的不良事件发生情况。结果治疗1个月后,两组脑钠肽(BNP)、肌钙蛋白I(Tn I)、肌酸激酶同工酶(CK-MB)水平均较治疗前明显改善,观察组BNP、Tn I、CK-MB水平明显低于对照组,差异有统计学意义(P<0.05)。治疗1个月后,两组左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)水平均较治疗前明显改善,且观察组LVEF水平高于对照组,LVEDD水平明显低于对照组,差异有统计学意义(P<0.05)。随访期间两组急性心肌梗死发生率比较,差异无统计学意义(P>0.05);与对照组比较,观察组心力衰竭、心绞痛、再次入院等发生率明显降低,差异有统计学意义(P<0.05)。结论 PCI治疗缺血性心肌病患者具有较高的应用价值,能有效提高患者心功能,改善血清BNP、Tn I、CK-MB水平,降低预后不良事件发生率,值得临床推广。Objective To investigate the application value of percutaneous coronary intervention （PCI） in the treatment of ischemic cardiomyopathy. Methods Ninety-six patients with ischemic cardiomyopathy admitted to Zhongxiang People＇s Hospital from February 2014 to April 2015 were selected and randomly divided into two groups by random coin tossing method, with 48 cases in each group. The control group received conventional drug therapy, on basis of which, the ob- servation group was given PCI. After treatment, the biochemical indexes, cardiac function and adverse events during follow-up in the two groups were compared. Results After treatment for 1 month, the levels of brain natriuretic peptide （BNP）, troponin I （TnI） and creatine kinase isoenzyme （CK-MB） in the two groups were all significantly improved com- pared with those before treatment, the levels of BNP, TnI, CK-MB in the observation group were significantly lower than those of control group, the differences were statistically significant （P 〈 0.05）. After treatment for 1 month, the levels of left ventricular ejection fraction （LVEF）, left ventricular end diastolic diameter （LVEDD） in the two groups were all significantly improved compared with those before treatment, the levels of LVEF in the observation group were significantly higher than those of control group, the levels of LVEDD in the observation group were significantly lower than those of control group, the differences were statistically significant （P 〈 0.05）. During follow-up, there was no statistically significant difference of the incidence of acute myocardial infarction between the two groups （P 〉 0.05）; compared with control group, the incidence of heart failure, angina and readmission in the observation group was significantly decreased, the differences were statistically significant （P 〈 0.05）. Conclusion PCI in the treatment of ischemie eardiomyopathy has high application value, which can effectively improve the cardiac function and the levels of

关 键 词：经皮冠状动脉介入治疗 缺血性心肌病 心功能 应用价值 

分 类 号：R542.22[医药卫生—心血管疾病]