基于数据挖掘的近50年中医治疗雄激素源性脱发用药分析  

Analysis of traditional Chinese medicine in the treatment of androgenetic alopecia in the past 50 years based on data mining

作　　者：吴承艳[1] 周雯 任威铭 张蕾 吴承玉[3] 卞雅莉[1] 

机构地区：[1]南京中医药大学中医药文献研究所,江苏南京210046 [2]南京中医药大学第一临床医学院,江苏南京210046 [3]南京中医药大学基础医学院,江苏南京210046

出　　处：《中国医药导报》2017年第32期166-169,F0003,共5页China Medical Herald

基　　金：江苏省科技厅自然科学基金资助项目(BK20131418);江苏省社会科学基金项目(13LSB007);江苏高校优势学科(中医学)资助项目(PAPD)

摘　　要：目的探讨近50年中医治疗雄激素源性脱发(AGA)的用药特点。方法通过收集整理1965年1月~2015年12月中医药公开发表治疗AGA的期刊文献,运用Excel软件创建脱发的用药数据库,从中研究这段时期中医治疗AGA的用药特点。结果在用药频次上,常用的内服药物包括当归、何首乌、熟地、川芎等,常用的外用药物包括侧柏叶、红花、当归、何首乌等。在用药分类上,补虚药占第一位,清热药、活血化瘀药其次。在药性上,偏温热性的药占大多数,偏寒凉的药其次。在归经上,入五脏的占大部分,诸脏中以入肝经最多,诸腑中以入胃经最多。结论近50年中医把补虚作为AGA的基本治法,在此基础上内治方再施以清泄内热、祛浊利湿、活血化瘀等治法,外治方辅以活血化瘀、辛散透邪、清热化湿等治法,注重内治与外治的结合,重视调养肝肾和脾胃,并兼顾AGA的心理,适当配以安神药的使用。Objective To explore the charaeteristics of traditional Chinese medicine in treating androgenetic alopecia （AGA） in the past 50 years. Methods Through the collection and eollation of Chinese medicine in the treatment of AGA published from January 1965 to Deeember 2015, exeel software was used to create a database for hair loss to study the eharacteristies of Chinese medicine for treating AGA in this period. Results In the frequeney of drug use, commonly used oral administration included Radix Angelicae Sinensis, Radix Polygoni Multiflori, Radix Rehmanniae Preparata, Rhizoma Ligustici Chuanxiong, etc; commonly used external drugs included Cacumen Platycladi, Flos Carthami, Radix Angelicae Sinensis, Radix Polygoni Multiflori, etc. In the kinds of herbal medication, tonic drugs accounted for the first, followed by heat-clearing drugs, removing blood stasis drugs. In the properties of herbal medication, hot property took the main part, cold medicine and medicine of the second, flat end. In the channel tropism, the five-zang herbs were in the majority, among all zang viscera, the herbs to the liver channel were the most, among all fu viscera, the herbs to the stomach channel were the most. Conclusion Nearly 50 years, traditional Chinese medicine take the tonic as AGA basic treatment, on the basis of which, internal treatment is added with the methods of clearing endogenous heat, dispelling turbid dampness, promoting blood circulation for removing blood stasis, etc, and the external treatment is supplemented by promoting blood circulation for removing blood stasis, dispersing and expelling pathogenic factors, clearing away heat and removing dampness, etc. traditional Chinese medicine pay attention to the combination of internal and external treatment, and the regulating of liver-kidney and spleen-stomach, taking into account the AGA psychology, accompanied by the appropriate use of sedative drugs.

关 键 词：雄激素源性脱发 数据挖掘 中医 用药 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]