儿童免疫性血小板减少症与食物不耐受的相关性研究  

Study on the relationship between immune thrombocytopenia and food intolerance in children

作　　者：范玮[1] 王淑梅 罗丹青[1] 师晓东[1] 

机构地区：[1]首都儿科研究所附属儿童医院血液科,北京100020 [2]北京首儿李桥儿童医院血液科,北京101314

出　　处：《中国医刊》2017年第11期62-65,共4页Chinese Journal of Medicine

摘　　要：目的探讨食物不耐受在儿童免疫性血小板减少症的发病机制及治疗中的意义。方法对2015年7月至2016年7月于首都儿科研究所附属儿童医院门诊就诊或住院治疗的113例免疫性血小板减少症患儿进行血清食物特异性抗体IgG检测。首先根据食物特异性抗体IgG水平将患儿分为两组,并进一步将食物特异性IgG抗体阳性患儿随机分为两组。第1组患儿为Ig G抗体阴性,采用药物治疗方案;第2组患儿为IgG抗体阳性,采用药物治疗方案;第3组患儿为Ig G抗体阳性,采用药物治疗联合检测阳性食物回避治疗方案。治疗2个月后对3组患儿的临床疗效进行比较分析。结果本研究中有81例(72%)患儿为食物特异性IgG抗体水平阳性,32例(28%)为食物特异性IgG抗体水平阴性;食物特异性抗体IgG升高以鸡蛋最多见,其次是牛奶。治疗2个月后,第1组患儿的症状改善总有效率为59.4%,第2组患儿为12.2%,第3组患儿为62.5%,第3组明显高于第2组(P<0.05)。结论食物不耐受可能是儿童免疫性血小板减少症的致病因素之一。饮食调整对治疗儿童免疫性血小板减少症具有一定疗效。Objective To explore the pathogenesis and treatment of food intolerance in children with immune thrombocytopenia. Method The detection of serum food specific antibody IgG were used in 113 cases of children with immune thrombocytopenia, which hospitalized or outpatients in July 2015 to July 2016. According to the samples of food specific IgG antibody level, we divided them into two groups. Subsequently we divided cases of the positive of food specific IgG antibody into two groups according to the random number table method. The first group is the IgG negative group, with drug treatment alone; The second group is the IgG positive group, with the drug treatment alone; and the third group is the IgG positive group, with the combination of drug treatment and positive food withdrawal. The clinical efficacy was compared between the three groups after treatment for two months. Result In this study, 81 cases （72%） were positive for food specific IgG antibody in total 113 cases, and 32 cases （28%） were negative. The increase of food specific antibody IgG was highest in eggs, followed by milk. 2 months later, the total effective rate of symptoms in the first group was 59.4% and in the second group was 12.2%, which was significantly lower than that of the third group（62.5）, and the difference was statistically significant（P〈 0.05）. Conclusion Food intolerance may be one of the pathogenic factors of immune thrombocytopenia in children, and the effect of diet adjustment on children with immune thrombocytopenia is obvious.

关 键 词：食物特异性抗体 食物不耐受 儿童 免疫性血小板减少 

分 类 号：R725.5[医药卫生—儿科]