血管紧张素转化酶2基因（rs879922）多态性与维吾尔族、汉族高血压患者左房扩大的相关性研究  

Correlation between angiotensin converting enzyme 2 gene（rs879922）polymorphism and left atrial enlargement in Uygur and Han nationality patients with hypertension

作　　者：刘城[1,2] 郭宝云 申艳[1] 黎艳芳[1] 赖艳娴[1] 赵海燕[2] 阿不都热西提·则亚维丁[2] 

机构地区：[1]广州市第一人民医院心血管内科,510180 [2]新疆维吾尔自治区喀什地区疏附县人民医院

出　　处：《中华生物医学工程杂志》2017年第1期6-10,共5页Chinese Journal of Biomedical Engineering

基　　金：新疆维吾尔自治区自然科学基金资助项目（201318101-12）;广东省科技计划项目（2014A020212372）

摘　　要：目的 探讨血管紧张素转化酶2（ACE2）基因多态性与维吾尔族、汉族高血压（EH）患者左房扩大的相关性及差异.方法 分别在新疆喀什地区维吾尔族、广东广州地区汉族人群中选取高血压患者324例（维吾尔族102例,汉族222例）为高血压组,以及相应地区健康人群212例（维吾尔族96例,汉族116例）为对照组,采用基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）技术检测ACE2基因rs879922位点多态性,并分析其与左房扩大的关系.结果 ACE2基因rs879922多态位点在广东广州汉族非高血压、高血压人群中基因型（P=0.546）、等位基因（P=0.777）分布差异无统计学意义,但其在新疆喀什维吾尔族非高血压、高血压人群中基因型（P=0.000）、等位基因（P=0.000）分布差异有统计学意义.在维吾尔族高血压人群中GG基因型明显高于非高血压人群,且经多因素Logistic回归分析,CG基因型人群发生高血压的风险高于CC等位基因人群（OR=10.322,95%CI：2.247-47.425,P=0.003）.更进一步地,在维吾尔族高血压人群中,携带CG基因型患者左房内径（3.67±0.43）明显较携带CC（3.08±0.35）、GG（3.15±0.40）两种基因型者增大明显（P=0.003）,而在维吾尔族非高血压人群中CC、CG、GG基因型（分别为2.93±0.36、2.95±0.08、2.93±0.32）的左房内径差异无统计学意义（P=0.985）.结论 ACE2基因rs879922多态位点与维吾尔族人群高血压相关,且该多态位点CG基因型与维吾尔族高血压人群早期靶器官损害左房扩大亦相关,是维吾尔族高血压的易感基因.Objective To investigate the correlation between angiotensin converting enzyme 2 （ACE2） gene polymorphism and left atrial enlargement in Uygur and Han patients with essential hypertension（EH）patients and their differences. Methods A total of 324 hypertensive patients（102 cases of Uygur and 222 cases of Han nationality）from Uygurpopulation of Kashgar in Xinjiang Uygur autonomous region and Han population of Guangzhou in Guangdong province were included as thehypertension group, and 212 healthy subjects from the corresponding areas（96 cases of Uygur and 116 cases of Han nationality） were included as the control group. The ACE2 gene（rs879922）polymorphismwas determined by matrix-assisted laser desorption ionization time-of-flight mass spectrometry （MALDI-TOF MS）. Results There＆amp;nbsp;were no statistically significant differences in the distribution of the genotype （P=0.546） and allele （P=0.777） of the ACE2 gene（rs879922）polymorphism between the non - hypertensive population and hypertensive Han population of Guangzhou in Guangdong province, whereas there were statistically significant differences in the distribution of the genotype（P=0.000）and allele（P=0.000）between the non-hypertensive population and hypertensive Uygur population of Kashgar inXinjiang. GG genotype in Uygur hypertensive population was significantly higher than that in non-hypertensive population. Multivariate logistic regression analysis showed that the risk of hypertension in the population with CG genotype was higher than that in the population with CC allele （OR=10.322, 95%CI：2.247-47.425, P=0.003）. Furthermore,in the Uygur hypertensive population,the size of left atrial diameter in Uygur hypertensive population with CG genotype（3.67 ± 0.43）was significantly enlarged compared with that in patients with CC genotype （3.08 ± 0.35） and GG genotype （3.15 ± 0.40）（P=0.003）. There were no statistically significant differences in Uygur non-hypertensive population with CC,CG and GG gen

关 键 词：基因多态性 维吾尔族 汉族 高血压 左房扩大 

分 类 号：R544.1[医药卫生—心血管疾病]