骨髓间充质干细胞治疗股骨头坏死的研究进展  

Research progress in treatment of osteonecrosis of femoral head with bone marrow mesenchymal stem cells

作　　者：黄思城 李宏宇[1] 

机构地区：[1]广西壮族自治区人民医院骨科,南宁530021

出　　处：《中国临床新医学》2017年第11期1110-1113,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西自然科学基金项目(编号:2014GXNSFAA118186)

摘　　要：股骨头坏死(osteonecrosis of femoral head,ONFH)是一种渐进性破坏髋关节功能的疾病,早期股骨头坏死如得到有效治疗,将减轻患者的痛苦,提高患者的生活质量。骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)在合适的微环境下对股骨头坏死局部有促进成骨和成血管作用,缓解或防止股骨头坏死的进一步恶化。近年来,BMSCs在股骨头坏死治疗中已经取得了令人满意的疗效,该文就当前骨科临床中使用BMSCs治疗股骨头坏死的各种方式进行综述,以期为临床治疗股骨头坏死提供指导。Osteonecrosis of femoral head（ ONFH） is a progressive damage function of the hip disease. Earlystage treatment of ONFH will alleviate the patients＇ pain and improve their quality of life. Bone marrow mesenchymal stem cells（ BMSCs） can promote osteogenesis and angiogenesis of blood vessels of local ONFH in a suitable microenvironment,relieve or prevent ONFH further deterioration. In recent years,BMSCs has achieved a satisfactory curative effect on the treatment of the femoral head necrosis. The research progress in the treatment of ONFH with BMSCs is reviewed in this paper to provide the guidance of BMSCs for clinical treatments.

关 键 词：骨髓间充质干细胞 股骨头坏死 髋关节功能 成骨作用 成血管作用 

分 类 号：R68[医药卫生—骨科学]