初均速法预测不同包装金银花药材的有效期  

Stable Life Prediction for Honeysuckle Under Different Packaging Conditions by Initial Average Rate Stability Test

作　　者：韩赟[1,2] 谷巍[1] 沈夕坤[2] 巢建国[1] 刘青芝[1] 桑晓华 蒋玲[1] 

机构地区：[1]南京中医药大学药学院,南京江苏210023 [2]苏州市中医医院药学部,苏州江苏213005

出　　处：《中药材》2017年第4期816-822,共7页Journal of Chinese Medicinal Materials

基　　金：江苏省中药优势学科Ⅱ期建设(ysxk-2014);江苏省中药资源产业化过程协同创新中心项目(ZDXMHT-1-5;ZDXM-3-24)

摘　　要：目的:采用初均速法研究温度和湿度对金银花稳定性的影响,预测不同包装条件下金银花药材的有效期,探讨金银花适宜的包装及贮藏条件。方法:通过温度和湿度加速试验,测定10种常用包装条件下金银花中绿原酸含量,分析不同包装金银花的降解动力学参数,以初均速法预测样品的有效期,并结合两年的留样贮藏试验判断结果的可靠性。结果:温度和湿度加速试验表明初均速lnv0i与1/T及Hr线性关系良好,预测得到常温常湿下不同包装金银花的有效期:玻璃瓶(棕色4.17年,透明4.01年);透明聚乙烯塑料薄膜袋(15丝3.62年,10丝1.52年,6丝0.84年);透明塑料瓶3.67年;白色塑料编织袋0.86年;编织袋内衬聚乙烯薄膜袋(加10丝2.82年,加6丝1.39年);无包装0.46年。两年留样观察的结果与初均速法预测结果基本相符。结论:初均速法可应用于预测多因子作用下金银花的有效期;大量金银花仓储时包装宜选用较厚的聚乙烯薄膜袋或编织袋内衬聚乙烯薄膜袋,家庭日常贮藏宜选择棕色玻璃瓶;贮藏时需置于阴凉干燥处,以保证其质量。Objective ：To study the influence of temperature and humidity on the stability of honeysuckle by initial average rate stability test, to predict the effective period of honeysuckle under different packaging conditions, and to explore the best packaging and stor- age conditions of honeysuckle. Methods： Measure the content of chlorogenic acid in honeysuckle under ten kinds of commonly used packaging by the temperature and humidity accelerated test. Analyze the degradation kinetics parameters of honeysuckle and predict the effective period of the sample by initial average rate stability test. The reliability of the results was judged by the retention test. Results ： The linear relationships between Inv0i,1/T and Hr were good. The term of validity of each sample under normal temperature and humidi- ty was predicted as follows：brown glass bottle,4. 17 years, and transparent glass,4.01 years;15 wire transparent polyethylene plastic film bag, 3.62 years, 10 wire, 1.52 years, and 6 wire, 0. 84 years ; transparent plastic bottle, 3.67 years ; white plastic woven bag, 0. 86 years;woven bag with 10 wire plastic film bag,2. 82 years, and with 6 wire plastic film bag, 1.39 years;no packaging,0. 46 years. The results of the retention tests were basically consistent with the predicted results by initial average rate stability test. Conclusion：The ini- tial average rate stability test can be applied to predict stable life of honeysuckle under multiple factors interaction. A large number of the storage of honeysuckle should choose thick plastic bags or plastic bag with woven bags,while daily storage should choose brown glass bottles. It should be stored in a cool and dry place,in order to ensure its quality.

关 键 词：初均速法 金银花 包装 贮藏 有效期 

分 类 号：R283.1[医药卫生—中药学]