2-(3-噻吩并[2,3-b]吡啶基)-3-羟基噻吩并[2,3-b]吡啶的合成及表征  

Syntheses and characteristic of2-( thieno[2,3-b]pyridin-3-yl) thieno[2,3-b]pyridin-3-ol

作　　者：王晓娟 冯洁[1] 吕天喜[1] 罗芳[1] 

机构地区：[1]浙江师范大学化学与生命科学学院,浙江金华321004

出　　处：《浙江师范大学学报（自然科学版）》2017年第4期422-426,共5页Journal of Zhejiang Normal University:Natural Sciences

基　　金：国家自然科学基金面上项目(21173197)

摘　　要：以2-羧甲基硫代烟酸为原料,水热法一步合成了一个新的噻吩并[2,3-b]吡啶类化合物——2-(3-噻吩并[2,3-b]吡啶基)-3-羟基噻吩并[2,3-b]吡啶,并通过单晶X-射线衍射实验、红外光谱等对其结构进行了表征.单晶X-射线衍射分析结果表明,该化合物属于单斜晶系,Pn空间群,a=1.225 76(4)nm,b=0.391 24(0)nm,c=1.354 28(5)nm,β=113.715(2)°,V=0.594 62(3)nm^3,Z=2,F(000)=294.运用逆合成分析法推测了由2-羧甲基硫代烟酸合成联二噻吩并[2,3-b]吡啶类化合物的反应机理.A new compound,2-（thieno[2,3-b]pyridin-3-yl）thieno[2,3-b]pyridin-3-ol,based on 2-carboxy-methylsulfanyl nicotinic acid was hydrothermally synthesized and characterized by single crystal X-ray diffrac-tion and IR spectrum.The compound was crystallized in monoclinic system with space group Pn,cell parame-ters of a=1.225 76（4）nm,b=0.391 24（0）nm,c=1.354 28（5）nm,β=113.715（2）°,V=0.594 62（3）nm^3,Z=2,F（000）=294.Using the inverse synthesis analysis,it was speculated on a mechanism for the reaction of 2-carboxymethylsulfanyl nicotinic acid synthesis of bis（dithieno[2,3-b]pyridine com-pounds,which would have potential application in synthesis of bis（dithieno[2,3-b]pyridine compounds and their derivatives.

关 键 词：2-(3-噻吩并[2 3-b]吡啶基)-3-羟基噻吩并[2 3-b]吡啶 逆合成分析法 晶体结构 水热法 

分 类 号：O626[理学—有机化学]