血脂对突发性聋预后的影响  

Effects of Blood Lipids on Prognosis of Sudden Sensorineural Hearing Loss

作　　者：刘阳云[1] 曹杭[1] 张彩霞[1] 江文[1] 陈琼[1] 张纪帅[1] 杨会[1] 

机构地区：[1]解放军第一六三中心医院(湖南师范大学医学院第二附属医院)耳鼻喉科,长沙410003

出　　处：《中华耳科学杂志》2017年第5期518-522,共5页Chinese Journal of Otology

摘　　要：目的研究血脂对突发性聋预后的影响,以便为临床上采取合适的干预措施提供理论依据。方法分析晨起空腹的63例高频和全频下降型突聋患者静脉血中低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、甘油三脂(TG)、血清总胆固醇(TC)、载脂蛋白β(Apo-β)、载脂蛋白a(Apo-A)的水平,分析血脂各指标与听力恢复的关系。结果听力下降程度及不同听力下降频率的突发性聋患者之间血脂各个指标的差异均没有统计学意义(P>0.05);听力恢复的程度与血脂各指标的差异均没有统计学意义(P>0.05);Logistic回归分析表明,TG、TC水平与疗效相关(P<0.05),其余各指标与疗效关系不明显(P>0.05)。结论血脂对突发性聋预后可能有一定的影响,是否有需要专门的降脂治疗,尚需进一步研究。Objective To study effects of blood lipids on the prognosis of sudden sensorineural hearing loss(SSHL), in order to provide theoretical basis for interventional measures in clinic. Method Levels of low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), triglyceride(TG), total cholesterol(TC), apolipoprotein B(Apo-B) and apolipoprotein A(Apo-A) were tested in 63 patients with SSHL of descending or flat types,and the relationship between serum lipids and hearing recovery analyzed. Results Each index of blood lipids demonstrated no statistically significant correlation with the degree or audiometric type of hearing loss(P>0.05), or with the level of hearing recovery(P>0.05). Logistic regression models showed that the level of TG and TC was correlated with treatment outcomes(P<0.05), but not the levels of other lipid indicators(P>0.05). Conclusions The data indicate that blood lipids may have impact on the prognosis of the SSHL, although whether specific lipid-lowering therapies are indicated requires further studies.

关 键 词：突发性聋 血脂 疗效 

分 类 号：R764[医药卫生—耳鼻咽喉科]