口服补铁剂的研发现状与发展趋势  

Current status and development trend of oral iron supplement

作　　者：毛宇 陈博 顾宁 

机构地区：[1]东南大学生物科学与医学工程学院,江苏省生物材料与器件重点实验室,生物电子学国家重点实验室,江苏南京210096 [2]苏州纳米科技协同创新中心,纳米药物与生物材料专业中心,江苏苏州215123

出　　处：《药学研究》2017年第11期621-626,共6页Journal of Pharmaceutical Research

基　　金：国家自然科学基金国际合作重点项目(No.61420106012);国家重大研发计划(No.2017YFA0104301)

摘　　要：缺铁性贫血会影响机体的氧代谢、能量代谢、造血作用等生命活动,一直是人们致力于攻克的全球最普遍的营养不良症。目前用于纠正缺铁性贫血的方法主要有食品强化、口服补铁与注射补铁等,其中口服补铁剂价格便宜、易吸收、生物利用率高且患者顺应性良好,是临床上应用最广的补铁方式。本文对传统口服补铁剂的研究及应用现状做了概略地介绍,结合新型口服补铁材料的研发情况对存在亟须研究的问题进行了讨论,展望了未来的发展前景。Iron deficiency anemia( IDA) is the worldwide most prevalent nutritional deficiency disorder,which people have been dedicating to eradicating.IDA would affect body's oxygen metabolism,energy metabolism,hematopoiesis and other life activities.Food fortification,oral iron supplement and parenteral iron supplement are mainly strategies to remedy IDA,among which oral iron supplement is the most widely applied in clinic due to cheap,easily absorb,high bioavailability and good compliance.In this article we introduced the study and application current states of traditional oral iron supplement summarily,discussed the issues which desiderate to be researched combined the research and development situations of novel oral iron supplement materials,and expected their development prospects.

关 键 词：缺铁性贫血 营养不良症 口服补铁剂 传统 新型 

分 类 号：R973[医药卫生—药品]