中青年非妊娠女性碘营养状态与甲状腺疾病及功能的关系研究  

Association of Iodine Nutrition and Thyroid Health Conditions among Middle-young Age Non Pregnant Women in Shengli Oilfield Areas

作　　者：井源[1] 张山山 高健[1] 姚霞[1] 陈启才[1] 

机构地区：[1]胜利油田中心医院,山东省东营市257000

出　　处：《中国全科医学》2017年第A02期61-64,共4页Chinese General Practice

摘　　要：目的调查胜利油田中青年非妊娠女性碘营养状态和甲状腺疾病,并分析二者的相互关系。方法以2012—2013年胜利油田中心医院体检的胜利油田中青年非妊娠女性为调查对象。进行问卷调查、体格检查,并进行尿碘检测、甲状腺功能、甲状腺相关抗体和甲状腺B超检查。结果调查总人群尿碘中位数为113.4μg/L。其中甲状腺疾病组413人,占44.36%,尿碘中位数112.7μg/L,与正常组比较差异无统计学意义(P>0.05);不同甲状腺疾病组尿碘水平比较,差异无统计学意义(P>0.05),不同尿碘水平者三碘甲状腺原氨酸(T_3)、甲状腺素(T_4)、游离三碘甲状腺原氨酸(FT_3)、游离甲状腺素(FT_4)、促甲状腺激素(TSH)水平比较,差异均无统计学意义(P>0.05)。甲状腺过氧化物酶抗体(TPOAb)阳性组及甲状腺球蛋白抗体(Tg Ab)阳性组尿碘水平均明显高于TPOAb阴性组及TgAb阴性组(P<0.05)。多因素Logistic回归分析结果显示,年龄[OR=1.040,95%CI(1.009,1.071)]及甲状腺抗体阳性[OR=5.680,95%CI(3.864,8.349)]为中青年非妊娠女性甲状腺疾病及功能异常的危险因素(P<0.05),而甲状腺疾病发病与尿碘水平[OR=0.985,95%CI(0.822,1.182)]无相关性(P>0.05)。结论胜利油田中青年非妊娠女性碘摄入充足,该人群甲状腺疾病及功能异常可能与年龄及甲状腺抗体阳性有关,与碘营养状态无关。Objective To investigate relationship between iodine nutrition and thyroid disease among middle-young non-pregnant women in Shengli Oilfield areas. Methods A total of 931 subjects were investigated. Serum thyroid hormones,thyroid autoantibodies, and urinary iodine concentration were determined, and type B ultrasonography of thyroid gland was performed in all participants. Results The median level of urinary iodine in 931 women was 113. 4 μg/L. Thyroid disease group was 413（ 44. 36%） and the median level of urinary iodine was 112. 7 μg/L. There was no significant statisical difference in median level of urinary iodine between thyroid disease group and normal group（ P 〉 0. 05）. There was no significant difference in urinary iodine levels between the groups of thyroid diseases（ P 〉 0. 05）. The levels of T3,T4,FT3,FT4 and TSH in the patients with different urinary iodine levels were not statistically significant（ P 〉 0. 05）. TPOAb positive group and Tg Ab positive group urinary iodine levels were significantly higher than TPOAb negative group and Tg Ab negative group（ P 〈 0. 05）.Multivariate Logistic regression analysis showed that age [OR = 1. 040,95% CI（ 1. 009,1. 071） ]and thyroid antibody positive[OR = 5. 680,95% CI（ 3. 864,8. 349） ]were important risk factors for middle-young non-pregnant women thyroid disease,and urinary iodine levels [OR = 0. 985,95% CI（ 0. 822,1. 182） ] was no correlation. Conclusion Iodine uptake in is sufficient in Shengli Oilfield areas. The thyroid disease may be associated with age and thyroid antibodies,not to the iodine status.

关 键 词：甲状腺疾病 碘 甲状腺功能亢进症 甲状腺功能减退症 

分 类 号：R581[医药卫生—内分泌]