厄贝沙坦联合阿托伐他汀治疗对糖尿病肾病患者C反应蛋白及胱抑素C的影响  

Effect of irbesartan combined with atorvastatin on C reactive protein and cystatin C of patients with diabetic nephropathy

作　　者：刘莉[1] 刘名鑫 牛世慧 卢泽君 王娜娜[1] 张玲 

机构地区：[1]安徽省合肥市第二人民医院肾内科,安徽合肥230011

出　　处：《实用临床医药杂志》2017年第21期33-35,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨厄贝沙坦联合常规治疗对糖尿病肾病患者C反应蛋白及胱抑素C的影响。方法选取60例糖尿病肾病患者,随机分为观察组30例和对照组30例,对照组给予常规治疗,观察组在对照组的基础上采用厄贝沙坦联合阿托伐他汀治疗。比较2组的治疗效果、C反应蛋白、肾功能、胱抑素C水平。结果观察组的总有效率为95.0%,显著高于对照组的75.0%(P<0.05)。观察组治疗后的TC、MAP显著低于对照组(P<0.05),CRP显著低于对照组(P<0.05)。观察组治疗后的Scr、UAER、Cys C均显著低于对照组(P<0.05)。2组的不良反应无显著差异(P>0.05)。结论厄贝沙坦联合阿托伐他汀能够显著改善糖尿病肾病患者的CRP和Cys C的水平,降低炎性反应,改善肾功能损伤,提高治疗效果,延缓病情的进展。ObjectiveTo explore the effect of irbesartan combined with atorvastatin on C reactive protein and cystatin C of patients with diabetic nephropathy. MethodsA total of 60 diabetic nephropathy patients were selected and randomly divided into observation group and control group, 30 cases in each group. The control group was treated with conventional treatment. On the basis of the control group, the observation group was treated with irbesartan and atorvastatin. Effect, CRP, renal function and cystatin C level were compared between two groups. ResultsIn the observation group, the total effective rate was 95.0%, which was significantly higher than 75.0% of control group （P〈0.05）. In the observation group, the TC, MAP after treatment were significantly lower than the control group （P〈0.05）, CRP was significantly lower than the control group （P〈0.05）. In the observation group, levels of Scr, UAER, CysC after treatment were significantly lower than the control group （P〈0.05）. There was no significant difference of adverse reactions between two groups （P〉0.05）. ConclusionIrbesartan combined with atorvastatin can significantly improve the levels of CRP and CysC in patients with diabetic nephropathy, reduce inflammatory response, improve renal function damage, improve treatment effect and delay the progress of the disease.

关 键 词：厄贝沙坦 阿托伐他汀 糖尿病肾病 C反应蛋白 胱抑素C 

分 类 号：R587.0[医药卫生—内分泌]