不同剂量羟考酮在瘢痕子宫剖产术中的效果比较  

Effect comparison of different doses between oxycodone hydrochloride in analgesia of patients with cesarean section of scar uterine

作　　者：黄少华[1] 黄丽敏 马灵 王亚娟[1] 吴艳红 

机构地区：[1]河北省保定市妇幼保健院麻醉科,河北保定071000

出　　处：《实用临床医药杂志》2017年第21期45-47,51,共4页Journal of Clinical Medicine in Practice

基　　金：河北省保定市科技局社会发展项目(17ZF085)

摘　　要：目的探讨不同剂量盐酸羟考酮在缓解瘢痕子宫患者剖宫产术中宫缩痛的效果。方法选取择期接受瘢痕子宫剖宫产手术的患者200例,根据随机数表法分为盐水对照组(C组)、0.05 mg/kg盐酸羟考酮组(E1组)、0.08 mg/kg盐酸羟考酮组(E2组)、0.1 mg/kg盐酸羟考酮组(E3组),每组50例。4组患者均接受剖宫产,比较4组患者用药后宫缩痛变化及镇痛效果、术中不良反应发生率。结果 E2、E3组患者用药后5、15、30 min的宫缩痛VAS评分均显著低于对照组、E1组(P<0.05);E2、E3组患者镇痛效果显著优于对照组、E1组(P<0.05);E3组患者用药不良反应发生率显著高于对照组、E1组、E2组(P<0.05)。结论针对瘢痕子宫患者剖宫产,在胎儿娩出后给予患者0.08 mg/kg盐酸羟考酮能有效缓解宫缩痛。ObjectiveTo explore the effects of different doses of oxycodone hydrochloride pretreatment on analgesia of patients with cesarean section of scar uterine. MethodsA total of 200 patients underwent cesarean section were selected and randomly divided into saline control group （group C）, 0.05 mg/kg hydrochloric acid oxalone group （group E1）, 0.08 mg/kg oxycodone hydrochloride group （group E2）, 0.1 mg/kg oxycodone hydrochloride group （group E3）, 50 cases in each group. Four groups were treated with cesarean section. The changes of intrauterine pain, analgesic effect and the incidence rate of adverse reactions were compared between the four groups. ResultsIn group E2 and E3, VAS score of contractions pain 5, 15, 30 min after treatment were significantly lower than the control group and group E1 （P〈0.05）. of patients Analgesic effect in group E2 and E3 was significantly better than the control group and group E1 （P〈0.05）. Incidence rate of drug induced adverse reaction in group E3 was significantly higher than the control group, group E1 and group E2 （P〈0.05）. ConclusionFor patients with cesarean section of scar uterine, 0.08 mg/kg oxycodone hydrochloride can effectively relieve uterine pain.

关 键 词：盐酸羟考酮 瘢痕子宫 剖宫产 宫缩痛 

分 类 号：R713.4[医药卫生—妇产科学]