宫颈上皮内瘤变Ⅰ与人类乳头状病毒感染型别的关系  

Correlation between cervical intraepithelial neoplasia Ⅰ and type of human papillomavirus infection

作　　者：苏莉[1] 于澎静 夏林[1] 

机构地区：[1]江苏省扬中市人民医院妇产科,江苏扬中212200

出　　处：《实用临床医药杂志》2017年第21期52-54,共3页Journal of Clinical Medicine in Practice

基　　金：江苏省镇江市社会发展指导性项目(FZ2015058)

摘　　要：目的评价扬中地区宫颈上皮内瘤变Ⅰ(CINⅠ)患者人类乳头状病毒(HPV)持续感染及消退型别特异性。方法选择116例确诊为CINⅠ的患者。分析患者HPV分型,每4个月随访TCT、HPV检测,记录HPV持续感染及消退时间。结果高危HPV中,HPV53(n=33)是最常见的亚型,其次分别是HPV52(n=25)、HPV68(n=22)、HPV66(n=20)、HPV16(n=14)。HPV多重感染常见,78例(67.2%)多重感染,38例(32.8%)单一感染。多重感染中,双重感染最常见(n=36,46.2%),其次是三重感染(n=28,35.9%)、四重感染(n=10,12.8%)、五重感染(n=3,3.8%)。10种最常见高危HPV中HPV16自行消退时间最长,平均为10.3月。结论扬中地区CINⅠ患者中HPV16是最常见的持续感染亚型。ObjectiveTo evaluate the specificity of continuous infection and decline of type of human papillomavirus （HPV） in women with cervical intraepithelial neoplasiaⅠ （CINⅠ） in Yangzhong area. MethodsA total of 116 patients with CINⅠwere selected. HPV typing was analyzed, and TCT and HPV were followed up every 4 months. The duration of HPV infection and regression time were recorded. ResultsIn the cases with high risk HPV, HPV53 （n=33） was the most common subtype, and followed by HPV52 （n=25）, HPV68 （n=22）, HPV66 （n=20） and HPV16 （n=14）. Multiple infections were common in HPV infection, including multiple infection in 78 cases （67.2%）, and single infection in 38 cases （32.8%）. In the multiple infections, dual infection was the most common type （n=36, 46.2%）, followed by triple infections （n=28, 35.9%）, four infections （n=10, 12.8%）, and five infections （n=3, 3.8%）. The HPV16 regression time was the longest in the ten most common high risk HPV, with an average of 10.3 months. ConclusionHPV 16 is the most common persistent HPV genotypes in women with CINⅠin Yangzhong area.

关 键 词：宫颈上皮内瘤变 人类乳头状病毒 基因型别 

分 类 号：R711.74[医药卫生—妇产科学]