地佐辛复合氟比洛芬酯对老年上腹部手术患者术后镇痛安全性与有效性的临床研究  

Clinical study on the safety and efficacy of dezocine combined with flurbiprofen axetil in postoperative analgesia in elderly patients undergoing upper abdominal surgery

作　　者：韩英[1] 邱雯[1] 吕培军[1] 赵劲松[1] 蒋永宽 

机构地区：[1]宁波市第六医院麻醉科,浙江省宁波315040

出　　处：《中国基层医药》2017年第23期3540-3543,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨地佐辛复合氟比洛芬酯对老年上腹部手术患者术后镇痛安全性与有效性.方法 选取80例择期行上腹部开腹手术的患者,按照随机数字表法分为研究组（T组）和观察组（C组）,每组40例,分别记录患者术后活动状态及静止状态下的出室即刻、术后2h、6h、12 h、24h、48 h视觉模拟评分（VAS）及Ramsay镇静评分.并记录患者48 h内嗜睡、寒战、术后恶心呕吐（PONV）、肺部感染等麻醉相关并发症发生情况.结果 在镇痛效果方面,两组患者静止状态及活动状态下出室即刻VAS评分差异均无统计学意义（t=0.287、0.436,均P＞0.05）.静止状态及活动状态下T组患者术后2h、6h、12h、24 h、48 h VAS评分显著低于C组患者（t=4.096、4.241、5.510、6.121、5.752、3.542、3.866、4.948、5.542、4.030,均P＜0.05）.在Ramsay镇静评分方面,两组患者出室即刻、术后2h、6h、12 h、24h、48 h时点Ramsay镇静评分差异均无统计学意义（t=0.323、0.226、0.541、0.297、0.771、0.795,均P＞0.05）.在术后镇痛不良反应方面,两组患者嗜睡、寒战、PONV、皮肤瘙痒、肺部感染发生率差异均无统计学意义（4例比6例,6例比5例,5例比3例,1例比3例,5例比1例,P=0.499、0.712、0.745、0.615、0.201）.结论 地佐辛复合氟比洛芬酯的术后镇痛配伍方式能够有效缓解老年上腹部手术患者的术后疼痛,提供了良好的术后镇痛效果,并且并未增加药物相关并发症的发生,值得在临床中推广使用.Objective To explore the safety and efficacy of dezocine combined with flurbiprofen axetil in postoperative analgesia in elderly patients undergoing upper abdominal surgery.Methods 80 patients underwent abdominalsurgery were selected.They were divided into study group（T group） and control group（C group） according to the random number table,40 cases in each group.The visual analogue scale（VAS） and Ramsay sedation score were recorded at 2h,6h,12h,24h,48h after operation,respectively.The anesthesia-related complications such as sleepiness,chills,postoperative nausea and vomiting （PONV）,and pulmonary infection in 48 hours were also recorded.Results There were no statistically significant differences in the VAS score between the two groups in the resting state and the active state（t =0.287,0.436,all P 〉 0.05）.The VAS scores of T group were significantly lower than those of C group at 2h,6h,12h,24h and 48h after operation （t =4.096,4.241,5.510,6.121,5.752,3.542,3.866,4.948,5.542,4.030,all P 〈 0.05）.There were no statistically significant differences in Ramsay sedation scores between the two groups at postoperative 2h,6h,12h,24h and 48h （t =0.323,0.226,0.541,0.297,0.771,0.795,all P 〉 0.05）.There were no statistically significant differences in the incidence of drowsiness,chills,PONV,skin itching and pulmonary infection in the two groups （4 cases vs.6 cases,6 cases vs.5 cases,5 cases vs.3 cases,1 case vs.3 cases,5 cases vs.1 case,P =0.499,0.712,0.745,0.615,0.201）.Conclusion The postoperative analgesic compatibility of dezocine combined with flurbiprofen axetil can effectively relieve the postoperative pain in elderly patients with upper abdominal surgery and provide good postoperative analgesic effect and does not increase the incidence of drug related complications.It is worth to promote in clinical.

关 键 词：外科手术 腹部 镇痛 地佐辛 氟比洛芬酯 老年人 

分 类 号：R614[医药卫生—麻醉学]