Selective biocompatibility and responsive imaging property of cationic conjugated polyelectrolyte to cancer cells  

作　　者：Bing Wang Chenyao Nie Libing Liu Fengting Lv Shu Wang 

机构地区：[1]Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

出　　处：《Chinese Chemical Letters》2017年第10期1975-1978,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China (Nos. 21473220 and 51573002);the Major Research Plan of China (No. 2013CB932800); the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB12030300)

摘　　要：Optical imaging, as an important molecular imaging modality, has emerged many attractions in studying the biological or molecular events both in cell level and living subject because of its high resolution and sensitivity, noninvasive manner and low cost. Herein, we bring novel insights into a water-soluble conjugated polyelectlyte by deeply studying its properties in cells. Poly（9, 9-bis（6＇-N,N,N-trimethylammonium hexyl）fluorene phenylene）（PFP）, a good biosensing material, was studied in this paper. The biocompatibility of PFP was investigated in different cells, and cell cycle analysis was carried out to explore the reasons of different biocompatibility of PFP to cells. After irradiation, fluorescence enhancement of blue emission and turn-on of long-wavelength emission of PFP in HepG2 cells was observed, which was first reported as far as we know. The differentiated biocompatibility of PFP and its particular imaging properties in cancer cells can help to guide the application of conjugated polymers in cells and provide a new dimension in designing sensitive and responsive imaging materials.Optical imaging, as an important molecular imaging modality, has emerged many attractions in studying the biological or molecular events both in cell level and living subject because of its high resolution and sensitivity, noninvasive manner and low cost. Herein, we bring novel insights into a water-soluble conjugated polyelectlyte by deeply studying its properties in cells. Poly（9, 9-bis（6＇-N,N,N-trimethylammonium hexyl）fluorene phenylene）（PFP）, a good biosensing material, was studied in this paper. The biocompatibility of PFP was investigated in different cells, and cell cycle analysis was carried out to explore the reasons of different biocompatibility of PFP to cells. After irradiation, fluorescence enhancement of blue emission and turn-on of long-wavelength emission of PFP in HepG2 cells was observed, which was first reported as far as we know. The differentiated biocompatibility of PFP and its particular imaging properties in cancer cells can help to guide the application of conjugated polymers in cells and provide a new dimension in designing sensitive and responsive imaging materials.

关 键 词：Imaging cell Conjugated polymers Fluorescence enhancement Long-wavelength emission Selective biocompatibility 

分 类 号：O631.3[理学—高分子化学] R318[理学—化学]