干扰素-γ基因多态性与原发性IgA肾病血尿和病理分级的相关性  

Relationship between interferon-gamma gene polymorphism and hematuria and pathological grades in IgA nephropalhy

作　　者：田园青[1] 贾妮亚[2] 张悦凤[1] 王彩丽[2] 

机构地区：[1]天津市海河医院,300350 [2]包头医学院第一附属医院

出　　处：《国际移植与血液净化杂志》2017年第5期33-35,共3页International Journal of Transplantation and Hemopurification

摘　　要：目的探讨干扰素-γ（interferon-gamma，IFN-γ）＋874A／T基因位点单核苷酸多态性与原发性Iga肾病（primary IgA nephropathy，IsAN）患者血尿和病理的关系。方法从131例IgAN患者和138例健康对照者外周血中提取DNA，采用序列特异性引物聚合酶链反应（PCR—SSP）技术检测IFN-y＋874A／T基因位点单核苷酸多态性，比较两组基因型和等位基因的分布，分析基因型与I酣N患者性别、血尿和病理关系。结果不同基因型发病与性别、镜下血尿和Hass病理分级无关（P〉0．05）。结论IFN．7基因＋874A／T基因位点单核苷酸多态性与IgAN患者性别、镜下血尿、Hass病理分级不存在相关性。Objective To Study the relationship between the single nucleotide polymorphism （SNP） in IFN-γ ＋ 874A/T and primary IgA nephropathy （IgAN） related hematuria and pathological grades. Methods DNA from 131 IgAN patients and 138 normal controls was extractal, and the SNP in IFN-γ ＋ 874A/T gene were determined by special sequence primer of polymerase chain reaction （PCR-SSP）. The genotype and allele distribution of the two groups were compared, and the relationship between genotype and gender, hematuria and pathological changes of tgAN patcents was analyzed. Results There was no significant difference in the incidence of different genotypes with sex, microscopic hematuria, and pathological grading of Hass （ P 〉 0.05）. Conclusion There is no correlation between IFN-7 ＋ 874A/T SNP and IgAN, gender, microscopic hematuria, Hass pathological grading.

关 键 词：干扰素 基因多态性 原发性IGA肾病 血尿 病理 

分 类 号：R692.31[医药卫生—泌尿科学]