Molecular dynamic simulation of the thermodynamic and kinetic properties of nucleotide base pair  

作　　者：王宇杰 王珍 王晏莉 张文炳 

机构地区：[1]Department of Physics, Wuhan University [2]Department of Physics and Telecommunication Engineering, Zhoukou Normal University

出　　处：《Chinese Physics B》2017年第12期1-6,共6页中国物理B（英文版）

基　　金：Project supported by the National Natural Science Foundation of China(Grant Nos.11574234 and 31270761)

摘　　要：A nucleotide base pair is the basic unit of RNA structures. Understanding the thermodynamic and kinetic properties of the closing and opening of a base pair is vital for quantitative understanding the biological functions of many RNA molecules. Due to the fast transition rate, it is difficult to directly observe opening and closing of single nucleic acid base pair in experiments. This review will provide a brief summary of the studies about the thermodynamic and kinetic properties of a base pair opening and closing by using molecular dynamic simulation methods.A nucleotide base pair is the basic unit of RNA structures. Understanding the thermodynamic and kinetic properties of the closing and opening of a base pair is vital for quantitative understanding the biological functions of many RNA molecules. Due to the fast transition rate, it is difficult to directly observe opening and closing of single nucleic acid base pair in experiments. This review will provide a brief summary of the studies about the thermodynamic and kinetic properties of a base pair opening and closing by using molecular dynamic simulation methods.

关 键 词：THERMODYNAMICS KINETICS molecular dynamic simulation 

分 类 号：Q52[生物学—生物化学]