Monte Carlo light transport-based blood vessel quantification using linear array photoacoustic tomography  

作　　者：蔺祥伟 孙明健 冯乃章 胡德鹏 沈毅 

机构地区：[1]Department of Control Science and Engineering, Harbin Institute of Technology, Harbin 150001, China

出　　处：《Chinese Optics Letters》2017年第11期73-77,共5页中国光学快报（英文版）

基　　金：partially supported by the National Natural Science Foundation of China(Nos.61371045 and 11574064);the Shenzhen Science&Technology Program,China(No.JCYJ20160429115309834);the Science and Technology Development Plan Project of Shandong Province,China(Nos.2015GGX103016 and 2016GGX103032);the China Postdoctoral Science Foundation(No.2015M571413)

摘　　要：Photoacoustic tomography is a noninvasive and nonionized biomedical imaging modality but it cannot reveal the inner structure and sideward boundary information of blood vessels in the linear array detection mode.In contrast,Monte Carlo（MC） light transport could provide the optical fluence distribution around the entire vascular area.This research explores the combination of linear array transducer-based photoacoustic tomography and MC light transport in the blood vessel quantification.Simulation,phantom,and in vivo experiments are in good correlation with the ultrasound imaging,validating this approach can clearly visualize the internal region of blood vessels from background tissue.Photoacoustic tomography is a noninvasive and nonionized biomedical imaging modality but it cannot reveal the inner structure and sideward boundary information of blood vessels in the linear array detection mode.In contrast,Monte Carlo（MC） light transport could provide the optical fluence distribution around the entire vascular area.This research explores the combination of linear array transducer-based photoacoustic tomography and MC light transport in the blood vessel quantification.Simulation,phantom,and in vivo experiments are in good correlation with the ultrasound imaging,validating this approach can clearly visualize the internal region of blood vessels from background tissue.

关 键 词：quantification TRANSDUCER MODALITY visualize NONINVASIVE registered reconstructed clearly compensated ARTIFACTS 

分 类 号：R318[医药卫生—生物医学工程] TP391.41[医药卫生—基础医学]